Petersen, Karina published the artcileToxicity of organic compounds from unresolved complex mixtures (UCMs) to primary fish hepatocytes, HPLC of Formula: 19156-54-8, the main research area is Oncorhynchus hepatocyte toxicity unresolved complex mixture; AhR agonist; Cytotoxicity; ER agonist; EROD; Naphthenic acids; Vitellogenin; Xenoestrogen; in vitro.
In the present study, several chems. with structures typical of those found in some UCMs, were assessed for their potential to disrupt membrane integrity, inhibit metabolic activity, activate the aryl hydrocarbon receptor (AhR), and activate the estrogen receptor (ER) in primary rainbow trout hepatocytes (Oncorhynchus mykiss). These endpoints were determined in order to screen for common toxic modes of action (MoA) in this diverse group of chems. EC50 values for cytotoxicity were obtained for 16 compounds and ranged from 77μM-24 mM, whereof aliphatic monocyclic acids, monoarom. acids, polycyclic monoarom. acids and alkylnaphthalenes were the most toxic. The observed cytotoxicity of the chems. correlated well with the hydrophobicity (LogKOW) suggesting that the toxicity was predominantly due to a non-specific MoA. Interestingly, two compounds induced the ER-mediated production of vitellogenin (Vtg) and six compounds induced the AhR-mediated Ethoxyresorufin-O-deethylase (EROD) enzymic activity to >20% of the pos. control; by doing so suggesting that they may act as ER or AhR agonists in fish. The heterogeneous group of ‘UCM compounds’ tested exhibited multiple MoA that may potentially cause adverse effects in fish. Addnl. studies to determine if these compounds may cause adverse effects in vivo at environmentally relevant concentrations, are warranted to identify if such compounds are indeed of potential environmental concern.
Aquatic Toxicology published new progress about Canned fish, rainbow trout. 19156-54-8 belongs to class benzothiophene, name is 4,5,6,7-Tetrahydrobenzo[b]thiophene-3-carboxylic acid, and the molecular formula is C9H10O2S, HPLC of Formula: 19156-54-8.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem