Li, DingXi published the artcileAsymmetric Synthesis of 1-Benzazepine Derivatives via Copper-Catalyzed Intramolecular Reductive Cyclization, Application In Synthesis of 1468-83-3, the main research area is benzazepine preparation diastereoselective enantioselective; dienyl arene ketimine reductive intramol cyclization copper catalyst.
An asym. construction of enantioenriched 2,3-substituted-1-benzazepine derivatives containing a cyclic tertiary amine moiety was developed by copper-catalyzed reductive intramol. cyclization of (E)-dienyl arenes with a tethered ketimine. This protocol involves tandem chemo-, regio-, and enantioselective hydrocupration and asym. cyclization in the presence of a chiral bisphosphine-copper catalyst. Under mild conditions, a broad range of 1-benzazepine derivatives I (R1 = H, 6-Me, 7-F, etc.; RL = C6H5, 4-BrC6H4, 4-MeOC6H4, etc.; RS = H, Me, Et, etc.) was obtained in good to high yields with high degrees of diastereoselectivity and enantioselectivity.
Organic Letters published new progress about Benzazepines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem