On September 12, 2013, Zhong, Zhaojin; Li, Zhuorong; Zhang, Dajun; Li, Yuhuan; Wang, Zhen; Gao, Rongmei; Shen, Jiajia published a patent.SDS of cas: 16296-68-7 The title of the patent was Preparation of phenyl oxazole derivatives as inosine monophosphate dehydrogenase inhibitors. And the patent contained the following:
Disclosed are Ph oxazolyl derivatives I [wherein R1 = H, halo, OH, alkyl, or alkoxy; R2 = absence, H, (un)substituted alkyl, CO2H, or sulfonyl; R = H, CN, (un)substituted alkyl, alkoxy, or aryloxy, etc.; p = 0-1; m = 0-3; n = 0-6] as an inosine monophosphate dehydrogenase (IMPDH) inhibitors for treating viral infection, neoplasm, and immune disease. For example, 3-methoxy-4-(oxazole-5-yl)aniline was reacted with 5-chloro-2-thiophenecarboxaldehyde to give II in 96.9% yield. In biol. test, II at 10 μg/mL showed 74.9% inhibition against IMPDH. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).SDS of cas: 16296-68-7
The Article related to preparation oxazole inosine monophosphate dehydrogenase inhibitor impdh human, treatment viral infection neoplasm immune disease, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.SDS of cas: 16296-68-7
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem