On May 6, 2021, Zhang, Yang; Wu, Wentao; Zhu, Wenyuan; Chen, Shuhui published a patent.Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid The title of the patent was Thiophene derivatives as xanthine oxidase inhibitors and application thereof. And the patent contained the following:
A class of xanthine oxidase (XO) inhibitors, and application thereof in the preparation of drugs for treating XO-related diseases. Specifically disclosed is a compound represented by formula I (R1 is independently selected from H, halide, OH, NH2, CN, etc.; n = 0, 1, 2, 3, or 4; R2 is selected from H, halide, OH, NH2 or CN; cyclic A is selected from C5-C6 cycloalkane or heterocylocalkane group) and a pharmaceutically acceptable salt thereof. For example, compound II is prepared by a multi-step synthesis starting from benzothiophene compound (CAS Number 2105532-70-3). The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
The Article related to thiophene derivative xanthine oxidase inhibitor drug disease, Heterocyclic Compounds (One Hetero Atom): Thiophenes and other aspects.Safety of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem