On June 22, 2017, Violin, Jonathan D.; Soergel, David G. published a patent.Electric Literature of 16296-68-7 The title of the patent was Preparation of opioid receptor ligands useful in combination with cytochrome P450 inhibitors for treatment of pain. And the patent contained the following:
This application describes compounds of formula I as opioid receptor ligands, and compositions comprising I in combination with cytochrome P 450 inhibitors, useful for the treatment of pain and pain-related disorders. Claimed is a pharmaceutical composition comprising I or a pharmaceutically salt of I [wherein R21 and R22 independently = H or CH3; D1 = (un)substituted aryl; B3 = H or (un)substituted alkyl; B5 = (un)substituted (hetero)aryl] and at least one CYP2D6 inhibitor and CYP3A4 inhibitor; and a pharmaceutically acceptable carrier. Example compound (R)-II was prepared from the reaction of benzaldehyde with 2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]ethan-1-amine in the presence of CH2Cl2 forming the corresponding imine which underwent reduction by NaBH4 affording the desired compound in 92% yield. Candidate compounds of I were evaluated for antinociceptive activity using an in vivo mouse model and hot plate assay from which (R)-II exhibited demonstrated 100% maximal possible effect at a dose of 10 mg/kg. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Electric Literature of 16296-68-7
The Article related to opioid receptor ligand preparation cytochrome p450 inhibitor combination pain, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Electric Literature of 16296-68-7
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem