On May 10, 2012, Robertson, Mark J.; Hadzic, Gordana; Ambrus, Joseph; Pome, D. Yuri; Hyde, Emily; Whiting, Ainslie; Mariana, Anna; von Kleist, Lisa; Chau, Ngoc; Haucke, Volker; Robinson, Phillip J.; McCluskey, Adam published an article.Quality Control of 5-Chlorobenzo[b]thiophene-3-carbaldehyde The title of the article was The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. And the article contained the following:
Six focused rhodanine-based libraries, 60 compounds in total, were synthesized and evaluated as potential dynamin I GTPase inhibitors. Twenty-six were more potent than the lead compound with 13 returning IC50 values ≤10 μM, making the Rhodadyn series among the most active dynamin inhibitors reported. Two analogs were highly effective at blocking receptor-mediated endocytosis: C10 and D10 (I) with IC50(RME) = 7.0 ± 2.2 and 5.9 ± 1.0 μM, resp. These compounds are equipotent with the best reported in-cell dynamin inhibitors. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Quality Control of 5-Chlorobenzo[b]thiophene-3-carbaldehyde
The Article related to dynamin gtpase inhibitor rhodanine analog preparation sar, knoevengal condensation, dynamin inhibition, rhodanine, Pharmacology: Structure-Activity and other aspects.Quality Control of 5-Chlorobenzo[b]thiophene-3-carbaldehyde
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem