Iddon, B.; Dickinson, R. P. published an article in 1971, the title of the article was Condensed thiophen ring systems. VI. Synthesis and reactions of 5-methyl- and 5-chloro-3-benzo[b]thienyllithium.Category: benzothiophene And the article contains the following content:
Bromination of 5-methyl- and 5-chlorobenzo[b]thiophene in CHCl3 gave 2,3-dibromo-5-methyl-, and a mixture of 20% 3-bromo-5-chloro- and 80% 2,3-dibromo-5-chlorothiophene, resp.; reaction of the 2,3-di-Br derivatives with BuLi-Et2O at 0° gave 3-bromo-5-methyl- (I) and 3-bromo-5-chlorobenzo[b]thien-2-yllithium (II). Reaction of I and II with CO2 gave the corresponding 2-carboxylic acids, and with HCl gave 5-methyl- (III) and 5-chloro-3-bromobenzo[b]thiophene (IV). Reaction of III and IV with BuLi-Et2O at -70° gave 5-methyl- (V) and 5-chlorobenzo[b]thien-3-yllithium (VI), resp. V and VI reacted with CO2, DMF, and Me2SO4 to give the corresponding 3-carboxylic acids, 3-carboxaldehydes, and 3-Me derivatives, resp. Huang-Minlon reduction of 5-methylbenzothio[b]phene-3-carboxaldehyde gave 3,5-dimethylbenzo[b]thiophene. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Category: benzothiophene
5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas:16296-68-7) belongs to benzothiophene. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP. Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem