El Shanta, M. S.; Scrowston, R. M. published an article in 1967, the title of the article was Preparation and properties of some 3-acetyl- and 3-formyl-5-halobenzo[b]thiophenes.Name: 5-Chlorobenzo[b]thiophene-3-carbaldehyde And the article contains the following content:
5-Chloro- and 5-bromobenzo[b]thiophene-3-carboxaldehydes (I) (X = Cl and Br) were prepared from the corresponding 3-bromomethyl compound either by the Sommelet reaction (65%) or by the Kroehnke reaction (30% yield). They had the usual properties of an aromatic aldehyde; in particular, they underwent the Doebner reaction with malonic acid, and formed crystalline condensation products with rhodanine. Friedel-Crafts acetylation of 5-chloro- or 5-bromobenzo[b]thiophene gave predominantly the 3-acetyl derivative This reacted with Me2NH.HCl and H2CO (Mannich reaction) to give the corresponding keto amine, the keto group of which was reduced with NaBH4. The resulting alcs. were treated with SOCl2 to give the corresponding substituted 3-chloropropylamines. 34 references. The experimental process involved the reaction of 5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas: 16296-68-7).Name: 5-Chlorobenzo[b]thiophene-3-carbaldehyde
5-Chlorobenzo[b]thiophene-3-carbaldehyde(cas:16296-68-7) belongs to benzothiophene. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP. Name: 5-Chlorobenzo[b]thiophene-3-carbaldehyde
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem