On August 26, 2015, Chen, Shuhui; Zhu, Wenyuan; Wang, Jianfei; Li, Jian; Wei, Yuquan; Yu, Luoting; Tao, Xin published a patent.Reference of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid The title of the patent was Thiophene-imidazole derivatives as hepatitis c virus inhibitors and their preparation, pharmaceutical compositions and use in the treatment of chronic hepatitis C virus infection. And the patent contained the following:
The invention discloses a series of thiophene or its variant derivative and composition as hepatitis C virus inhibitor, and relating to its application in preparation chronic HCV infection treatment medicine.In particular it relates to the series compound as NS5A inhibitor and composition thereof and pharmaceutical applications. Disclosed is thiophene-imidazole derivatives, e.g., I, as hepatitis C virus (HCV) inhibitors or variant derivatives thereof and compositions thereof. The invention further relates to the application in preparing chronic hepatitis C virus infection drugs. Particularly, the invention relates to a series of compounds used as NS5A inhibitors and compositions thereof and uses thereof for drug preparation Compound I was prepared by using cyclization, cross-coupling and condensation as the key steps. All the invention compounds were evaluated for their hepatitis c virus and NS5A inhibitory activity. From the assay, it was determined that example compound I exhibited the EC50 and CC50 values of 0.001 – 0.1 nM and > 10 nM against HCV 1b. The experimental process involved the reaction of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid(cas: 188240-63-3).Reference of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
The Article related to thiophene imidazole preparation ns5a inhibitor treatment chronic hepatitis c, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Bromo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylic acid
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem