《Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control》 was published in Organic Letters in 2020. These research results belong to Saito, Kodai; Miyashita, Hiromitsu; Ito, Yui; Yamanaka, Masahiro; Akiyama, Takahiko. Reference of 1-Thiophen-2-yl-ethanone The article mentions the following:
An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key to success of the title reaction was the equilibrium control by adjusting the ratio of the resolving reagent and unique enantiodivergence was observed depending on the equilibrium displacement. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Reference of 1-Thiophen-2-yl-ethanone
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem