Day: October 19, 2022

In 2019,Tetrahedron Letters included an article by Sahoo, Debasis; Sarkar, Sohini; Jana, Samaresh. Recommanded Product: 88-15-3. The article was titled 《A simple synthesis of ketone from carboxylic acid using tosyl chloride as an activator》. The information in the text is summarized as follows:

An effective process for the conversion of carboxylic acids to ketones was discovered. In this process, carboxylic acid was activated using p-toluene sulfonyl group. Under the optimized condition, aromatic, aliphatic heteroaromatic carboxylic acids was proved to be good substrates for this methodol. The byproduct of this reaction can be removed very easily during work up process. Also, one equivalent of organometallic reagent was sufficient to complete this transformation. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 88-15-3) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Recommanded Product: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2022,Paganelli, Stefano; Tassini, Riccardo; Piccolo, Oreste published an article in ChemistrySelect. The title of the article was 《Sustainable Synthesis of Aryl and Heteroaryl Aldehydes》.Recommanded Product: 1-Thiophen-2-yl-ethanone The author mentioned the following in the article:

In this paper, authors’ focused on the synthesis of some (hetero)aromatic aldehydes, used either as industrial flavor/fragrances of com. interest, such as heliotropine, or as key intermediates for the preparation of some APIs and of other fragrances such as lioral and helional, by reductive carbonylation of halo derivative precursors. In order to carry out an easier and more applicable process, hydrogen donors, instead of gaseous flammable and explosive hydrogen, and recyclable phosphine free low metal content catalysts, were employed. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Recommanded Product: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Metalation of 3-thiophenecarboxaldehyde ethylene acetal-the tautomeric structure of 3-formyl-2-thiophenecarboxylic acid》 was published in Arkiv foer Kemi in 1963. These research results belong to Gronowitz, Salo; Gestblom, Bo; Mathiasson, Birgitta. Category: benzothiophene The article mentions the following:

Metalation of 3-thiophenecarboxaldehyde ethylene acetal, b10 103-4°, with BuLi, followed by carbonation gave 78% 3formyl-2-thiophenecarboxylic acid (I), m. 130-1° (C6H6-ligroine). I was identified by mutual coupling of the thiophenic ring hydrogens at 5.2 cycles/sec. in the nuclear magnetic resonance (n.m.r.) spectrum and Ag2O oxidation of I to 2,3-thiophenedicarboxylic acid. The infrared spectrum of I in KBr showed C:O stretching frequencies at 5.87 and 6.09 μ, and no OH stretching absorption at 3 μ. I gave no Me ester on refluxing with MeOH without acid, but with acid a Me ester (II), m. 61-2°; v 5.81, 5.96 μ (KBr). Thus, I must exist in the open aldehydocarboxylic acid structure. The n.m.r, spectra are given for I, II, phthalaldehydic acid (III), the Me ester of III, and the anion of III in Me2CO, dioxane, CHCl3, and H2O. These spectra support the open form of I and the cyclic nature of III. In addition to this study using 2-(Thiophen-3-yl)-1,3-dioxolane, there are many other studies that have used 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Category: benzothiophene) was used in this study.

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Thiophene isosters of isoquinoline. VI. Synthesis of 4,5-dimethylthieno[2,3-c]pyridine and 6,7-dimethylthieno[3,2-c]pyridine》 was published in Chemica Scripta in 1975. These research results belong to Sandberg, Elina. SDS of cas: 13250-82-3 The article mentions the following:

4,7-Dimethylthieno[2,3-c]pyridine (I) was synthesized by hydrolyzing the acetal function in 2-amino-3-[2-(1,3-dioxolan-2-yl)-3-thienyl]butan-3-ol (II) leading to the ring-closed and dehydrated product. The amine was obtained by the reaction of 2-(3-lithio-2-thienyl)-1,3-dioxolane with diacetyl, followed by oximation and reduction 6,7-Dimethylthieno[3,2-c]pyridine (III) was obtained in an analogous manner. The experimental part of the paper was very detailed, including the reaction process of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3SDS of cas: 13250-82-3)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.SDS of cas: 13250-82-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 1988,Chemica Scripta included an article by Gronowitz, Salo; Hoernfeldt, Anna Britta; Yang, Youhua. SDS of cas: 13250-82-3. The article was titled 《Synthesis of dithienopyridines through palladium(0)-catalyzed coupling of 2-tributylstannyl-2-thiophenecarboxaldehyde with t-butyl N-(ortho-halothienyl)carbamates》. The information in the text is summarized as follows:

The title aldehyde (I) reacted with N-(o-halothienyl)carbamate esters, such as carbamate II, and Pd(PPh3)4 to give dithienopyridines III (R1R2 = CH:CHS, SCH:CH) and IV. I, tert-Bu N-(3-iodo-2-thienyl)carbamate, and Pd(PPh3)4 gave III (R1R2 = SCH:CH). The results came from multiple reactions, including the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3SDS of cas: 13250-82-3)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.SDS of cas: 13250-82-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Benzodithiophenes. A general method of synthesis》 were Gronowitz, Salo; Dahlgren, Torsten. And the article was published in Chemica Scripta in 1977. Recommanded Product: 2-(Thiophen-3-yl)-1,3-dioxolane The author mentioned the following in the article:

Through the Wittig reaction between o-bromoformylthiophenes and o-bromothenyltriphenylphosphoranes all six cis-1,2-di(o-bromothienyl)ethenes could be obtained. Halogen-metal exchange of these compounds with BuLi followed by reaction with CuCl2 yielded all six benzodithiophenes which are analogous to phenanthrene, namely benzo[1,2-b:4,3-b’]dithiophene, benzo[2,1-b:3,4-b’]dithiophene, benzo[1,2-b:3,4-b’]dithiophene, benzo[1,2-b:3,4-c’]dithiophene, benzo[2,1-b:3,4-c’]dithiophene and benzo[1,2-c:3,4-c’]dithiophene. The [b,c]-fused systems, although relatively stable in solution, could not be isolated due to dimerization or polymerization They could be characterized by reaction with di-Me acetylenedicarboxylate. After S extrusion, 7,8-dicarbomethoxynaphtho[2,1-b]thiophene and 7,8-dicarbomethoxynaphtho[1,2-b]thiophene are formed from the corresponding cycloaddition products. The other four benzodithiophenes did not react in the Diels-Alder reaction. The results came from multiple reactions, including the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Recommanded Product: 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Recommanded Product: 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem