In 2022,Paganelli, Stefano; Tassini, Riccardo; Piccolo, Oreste published an article in ChemistrySelect. The title of the article was 《Sustainable Synthesis of Aryl and Heteroaryl Aldehydes》.Recommanded Product: 1-Thiophen-2-yl-ethanone The author mentioned the following in the article:
In this paper, authors’ focused on the synthesis of some (hetero)aromatic aldehydes, used either as industrial flavor/fragrances of com. interest, such as heliotropine, or as key intermediates for the preparation of some APIs and of other fragrances such as lioral and helional, by reductive carbonylation of halo derivative precursors. In order to carry out an easier and more applicable process, hydrogen donors, instead of gaseous flammable and explosive hydrogen, and recyclable phosphine free low metal content catalysts, were employed. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 1-Thiophen-2-yl-ethanone)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Recommanded Product: 1-Thiophen-2-yl-ethanone
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem