The author of 《Four-component thiazole formation from simple chemicals under metal-free conditions》 were Jiang, Jingjing; Huang, Huawen; Deng, Guo-Jun. And the article was published in Green Chemistry in 2019. Reference of 1-Thiophen-2-yl-ethanone The author mentioned the following in the article:
Multi-component reactions for the synthesis of polysubstituted thiazoles from simple chems. were described. Under metal-free reaction conditions, cheap and easily available ketones, aldehydes, ammonium salt and elemental sulfur were self-assembled to provided entries to three thiazoles in moderate to good yield with a range of functionalities tolerated. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone) was used in this study.
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Reference of 1-Thiophen-2-yl-ethanone
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem