《Metalation of 3-thiophenecarboxaldehyde ethylene acetal-the tautomeric structure of 3-formyl-2-thiophenecarboxylic acid》 was published in Arkiv foer Kemi in 1963. These research results belong to Gronowitz, Salo; Gestblom, Bo; Mathiasson, Birgitta. Category: benzothiophene The article mentions the following:
Metalation of 3-thiophenecarboxaldehyde ethylene acetal, b10 103-4°, with BuLi, followed by carbonation gave 78% 3formyl-2-thiophenecarboxylic acid (I), m. 130-1° (C6H6-ligroine). I was identified by mutual coupling of the thiophenic ring hydrogens at 5.2 cycles/sec. in the nuclear magnetic resonance (n.m.r.) spectrum and Ag2O oxidation of I to 2,3-thiophenedicarboxylic acid. The infrared spectrum of I in KBr showed C:O stretching frequencies at 5.87 and 6.09 μ, and no OH stretching absorption at 3 μ. I gave no Me ester on refluxing with MeOH without acid, but with acid a Me ester (II), m. 61-2°; v 5.81, 5.96 μ (KBr). Thus, I must exist in the open aldehydocarboxylic acid structure. The n.m.r, spectra are given for I, II, phthalaldehydic acid (III), the Me ester of III, and the anion of III in Me2CO, dioxane, CHCl3, and H2O. These spectra support the open form of I and the cyclic nature of III. In addition to this study using 2-(Thiophen-3-yl)-1,3-dioxolane, there are many other studies that have used 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Category: benzothiophene) was used in this study.
2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem