Application In Synthesis of 4-Fluorobenzo[b]thiophene-2-carboxylic acidOn May 8, 2013 ,《Acid controlled generation of indanes and oxazolines from β-hydroxyarylethanamide》 appeared in Tetrahedron Letters. The author of the article were Suresh, Rajendran; Muthusubramanian, Shanmugam; Boominathan, Muthusamy; Manickam, Govindaswamy. The article conveys some information:
Simple and efficient protocols for the construction of substituted indans and oxazolines through intramol. cyclization of β-hydroxyarylethanamide using trifluoromethanesulfonic acid and titanium tetrachloride in 1,2-dichloroethane, resp., have been described. The selectivity due to different acid catalysts was explored and optimized to achieve good to excellent yield. E.g., in presence of TiCl4 in 1,2-dichloroethane, intramol. cyclization of β-hydroxyarylethanamide derivative (I, a mixture of diastereomers) gave 94% oxazoline derivative (II). E.g., in presence of trifluoromethanesulfonic acid, intramol. cyclization of β-hydroxyarylethanamide derivative (I, a mixture of diastereomers) gave 89% indan derivative (III). The results came from multiple reactions, including the reaction of 4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6Application In Synthesis of 4-Fluorobenzo[b]thiophene-2-carboxylic acid)
4-Fluorobenzo[b]thiophene-2-carboxylic acid(cas: 310466-37-6) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products. Application In Synthesis of 4-Fluorobenzo[b]thiophene-2-carboxylic acid
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem