Day: October 17, 2022

《Iodide-Selective PVC Membrane Electrode Based on Copper Complex of 2-Acetylthiophene Semicarbazone as Carrier》 was written by Suman, Shankar; Singh, Ram. Formula: C6H6OS And the article was included in Analytical Chemistry Letters in 2020. The article conveys some information:

A highly selective poly(vinyl chloride) (PVC) membrane electrode based on copper (II) complex of 2 acetylthiophene semicarbazone as a new carrier for iodide selective electrode is fabricated with the composition of PVC (30%), plasticizer (64%), ionophore (4%) and lipophilic additive (2%). The prepared electrode has been found to exhibit the best sensitivity over a wide concentration range of 1×10-6 to 3.2×10-2 M with a near Nernstian response of 57.2 mV per decade over a wide pH range of 2.5 10.5. The detection limit for the electrode was found to be 5.50×10-7 M with the response time of 15 s and can be used for at least 3 mo without any considerable divergence in its potential response. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Formula: C6H6OS) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Synthesis, single crystal structure, DNA binding and antioxidant properties of 5-(4-(dimethylamino)phenyl)-3-(thiophen-2-yl)-pyrazoline-1-carbothioamide》 was written by Rana, Manish; Fatima, Aysha; Siddiqui, Nazia; Dar, Sajad Hussain; Javed, Saleem; Rahisuddin. Reference of 1-Thiophen-2-yl-ethanoneThis research focused onthiophenyl pyrazoline carbothioamide preparation crystal structure DNA binding antioxidant. The article conveys some information:

5-(4-(Dimethylamino)phenyl)-3-(thiophen-2-yl)-pyrazoline-1-carbothioamide I was synthesized. The compound shows strong antioxidant activity with IC50 value of 0.632 ± 0.002μg/mL. The compound crystallizes as a monoclinic system, P21/c centro-sym. space group, Z = 8 and size of the corresponding unit cell: a = 11.7134(10) Å , b = 17.3334(15) Å , c = 16.9831(14) Å , α = 90, β = 108.038(2), γ = 90. DNA binding measurements (UV-vis., fluorescence, cyclic voltammetry and competitive assay using ethidium bromide) of compounds showed intercalative mode of interaction. The binding constant (Kb), Gibbs free energy (ΔG) of compound I were found to be 1.3 x 105 M-1 and -67.17 KJmol-1, resp. The calculated Ksv values at two different temperatures (298 and 303 K) are 3.02 x 103 and 2.16 x 103 M-1 resp. To optimize mol. structure and compute wavenumbers of normal vibrational modes, B3LYP method and 6-311 ++ G (d, p) basis set were used. Hirshfeld surface anal. provides a thorough illustration of the intermol. interactions on crystal surface, and fingerprint plots were discovered. Exptl. bond lengths and bond angles corroborated well with the computational parameters. The GIAO approach was used to estimate 1H-NMR and 13C-NMR chem. shifts, and compared to exptl. spectra. Electronic properties such as UV-Vis (in gas phase, ethanol and DMSO) were analyzed using TD-DFT method and the PCM solvent model, and results were compared to exptl. UV-Vis spectra. In the part of experimental materials, we found many familiar compounds, such as 1-Thiophen-2-yl-ethanone(cas: 88-15-3Reference of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Reference of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem