Day: October 17, 2022

In 2019,Current Organic Synthesis included an article by Su, Biyun; Li, Yaning; Pan, Dandan; Faida, Paison; Yan, Tingyu; Qu, Zhan. Quality Control of 1-Thiophen-2-yl-ethanone. The article was titled 《Microwave Irradiation Syntheses and Crystal Structures of Two Series of Novel Fivemembered Heterocyclic Mono-Imine Compounds》. The information in the text is summarized as follows:

In order to increase the coordination ability of heteroatom N and S to center metals, CH3 group was introduced into the side arm of pyrrole imine and thiophene imine resp., to get two series of novel five-membered heterocyclic imine compounds, mono(imino)pyrroles and mono(imino)thiophenes. Two series of novel five-membered heterocyclic compounds with the mono-imine group were synthesized from the p-toluene sulfonic acid catalyzed Schiff base condensation of anilines and 2-acetylpyrrole/ 2-acetylthiophene resp., using CH3 group to substitute the common H atom on the side arm of pyrrole imine/ thiophene imine. All the heterocyclic mono-imine compounds were characterized adequately by means of 1H NMR, 13C NMR, FT-IR, elementary anal., as well as X-ray crystallog. diffraction. The reactivity differences between two precursor 2-acetylpyrrole and 2-acetylthiophene with aromatic amines were compared and discussed in detail. Compared to traditional heating methods, the solvent-free microwave irradiation seemed more efficient to prepare these series of five-membered heterocyclic mono-imine compounds, which resulted in a higher yield and cleaner product. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Quality Control of 1-Thiophen-2-yl-ethanone) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Quality Control of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《PTSA-Catalyzed Reaction of Alkyl/Aryl Methyl Ketones with Aliphatic Alcohols in the Presence of Selenium Dioxide: A Protocol for the Generation of an α-Ketoacetals Library》 were Shangpliang, O. Risuklang; Wanniang, Kmendashisha; Kshiar, Baskhemlang; Marpna, Ibakyntiew D.; Lipon, Tyrchain Mitre; Mizar, Pushpak; Myrboh, Bekington. And the article was published in ACS Omega in 2019. Application of 88-15-3 The author mentioned the following in the article:

A novel approach has been developed for the synthesis of a wide range of α-ketoacetals by the reaction of alkyl/aryl Me ketones and aliphatic alcs. in presence of selenium dioxide catalyzed by p-toluenesulfonic acid (PTSA). This method represents a general route to obtain a wide variety of α-ketoacetals in a simple, rapid and practical manner. This approach is particularly attractive because of the easily availability of the starting materials, mild reaction temperature and good yields of the products. The resulting α-ketoacetals are of much synthetic value as organic intermediates. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Application of 88-15-3) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Application of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Direct synthesis of secondary amides from ketones through Beckmann rearrangement using O-(mesitylsulfonyl)hydroxylamine》 was written by Chandra, Dinesh; Verma, Saumya; Pandey, Chandra Bhan; Yadav, Ajay K.; Kumar, Puneet; Tiwari, Bhoopendra; Jat, Jawahar L.. Safety of 1-Thiophen-2-yl-ethanone And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

A highly efficient direct method for the preparation of secondary amides and lactams from ketones using O-(mesitylsulfonyl)hydroxylamine (MSH) was developed. The reactions proceeded rapidly at room temperature under mild condition without requiring any additive and tolerate multiple functional groups. A simple aqueous work-up often furnished the products in excellent yield with high purity. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Safety of 1-Thiophen-2-yl-ethanone) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Safety of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Kuzu, Burak; Ekmekci, Zeynep; Tan, Meltem; Menges, Nurettin published an article in 2021. The article was titled 《Excited State Intramolecular Proton Transfer (ESIPT)-Based Sensor for Ion Detection》, and you may find the article in Journal of Fluorescence.COA of Formula: C6H6OS The information in the text is summarized as follows:

C-2 and C-5 substituted imidazole skeleton was synthesized through a one-pot two-step strategy. Synthesized mol. emits the light on ESIPT (excited-state intramol. proton transfer). This mol. was utilized for its proton donor ability, and we have observed that fluoride and cyanide ions can be detected selectively. Different cations and anions were selected to observe the response of the synthesized mol. However, there were not any fluorometric and colorimetric response except for fluoride and cyanide ions. Detection limits of fluoride and cyanide ions were found to be 9.22μM and 11.48μM, resp. 1H-NMR spectra for the solution of the sensor and TBAF (tetrabuthylammoniumfluoride) were used for the identification of [L]-[HF2]- species. 3 equivalent TBAF saturated the solution of the sensor in d6-DMSO, and some of the proton resonances shifted to upfield due to the through-bond effect. The disappearance of NH proton with 0.5 equivalent TBAF or TBACN (tetrabuthylammoniumcyanide) showed that there was a proton abstraction by fluoride and cyanide ions, instead of the hydrogen bond. Solid-state application was utilized, and paper test strips were applied. Emission differences emerged when the sensor loaded strips were reacted with TBAF. Time resolved experiments revealed that solution of the sensor and TBAF in DMSO have multiexponential decay, and one of the lifetime was measured as 13.4 ns. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. COA of Formula: C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Li, Chung-Yen; Su, Chaochin; Wang, Hsiou-Hsuan; Kumaresan, Prabakaran; Hsu, Chia-Hsuan; Lee, I.-Ting; Chang, Wei-Chun; Tingare, Yogesh S.; Li, Ting-Yu; Lin, Chia-Feng; Li, Wen-Ren published an article on January 31 ,2014. The article was titled 《Design and development of cyclometalated ruthenium complexes containing thiophenyl-pyridine ligand for dye-sensitized solar cells》, and you may find the article in Dyes and Pigments.SDS of cas: 220180-55-2 The information in the text is summarized as follows:

Two new cyclometalated Ru sensitizers NC102(1) and NC103(2), where the 2 NCS- ligands of the N3 analog were replaced with the 2-thiophen-2-yl-pyridine and 2-benzo[b]thiophen-2-yl-pyridine ligands, resp., were designed and synthesized for dye-sensitized solar cell applications. The effects of these 2 ligands on the photophys. behavior of Ru complexes were studied by their optical, electrochem., and photovoltaic properties. The sensitizer NC103(2) with the fluoride substitution in the ligand exhibited the best cell performance with a short-circuit current (Jsc) of 9.45 mA/cm2, an open-circuit voltage (Voc) of 630 mV, and a fill factor (FF) of 0.71, giving an overall power conversion efficiency of (η) 4.22% under simulated AM 1.5 irradiation In addition to this study using Methyl 4-fluorobenzo[b]thiophene-2-carboxylate, there are many other studies that have used Methyl 4-fluorobenzo[b]thiophene-2-carboxylate(cas: 220180-55-2SDS of cas: 220180-55-2) was used in this study.

Methyl 4-fluorobenzo[b]thiophene-2-carboxylate(cas: 220180-55-2) belongs to benzothiophene.Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It has been used as a raw material for the synthesis of biologically active structures and is found in pharmaceuticals such as selective estrogen receptor modulators, leukotriene synthesis inhibitors and antifungals, as well as in many natural products. SDS of cas: 220180-55-2

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Dalton Transactions included an article by Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj. Quality Control of 1-Thiophen-2-yl-ethanone. The article was titled 《Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines》. The information in the text is summarized as follows:

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism. After reading the article, we found that the author used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Quality Control of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Quality Control of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,Journal of Fluorescence included an article by Kolbus, Anna; Danel, Andrzej; Grabka, Danuta; Kucharek, Mateusz; Szary, Karol. Name: 1-Thiophen-2-yl-ethanone. The article was titled 《Spectral Properties of Highly Emissive Derivative of Coumarin with N,N-Diethylamino, Nitrile and Tiophenecarbonyl Moieties in Water-Methanol Mixture》. The information in the text is summarized as follows:

The new derivative of coumarin (E)-3-[7-(diethyloamino)-2-oxo-chromen-3yl]-2-(tiophene-2-carbonyl)prop-2-enenitrile (NOSQ) was easy synthesized with com. substrates as a result of the search of new Michael type addition sensors based on coumarins. Spectral properties of highly emissive NOSQ were investigated by steady state anal. (absorption and fluorescence measurements) and time-resolved anal. (fluorescence lifetime measurements). The effect of water-methanol mixture on the photophys. properties of the NOSQ mol. was analyzed. With increasing of volumetric fraction of water the intensity of absorbance and fluorescence was strongly reduced. The NOSQ quantum yield in methanol was quite high and the first portions of water caused a significant increase in this value. Water, which is usually a quencher, in this case caused the increase in the quantum yield. The fluorescence lifetimes had second-order decay and the values of fluorescence lifetime increased with increasing alc. content. D. functional theory (DFT) calculations and exptl. data remained in agreement and showed that the interaction between the NOSQ mol. and the solvent affects the appearance of the new conformer. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Name: 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Name: 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2019,New Journal of Chemistry included an article by Wang, Weifan; Luo, Man; Yao, Weiwei; Ma, Mengtao; Pullarkat, Sumod A.; Xu, Li; Leung, Pak-Hing. Recommanded Product: 88-15-3. The article was titled 《Catalyst-free and solvent-free hydroboration of ketones》. The information in the text is summarized as follows:

The hydroboration of a wide range of ketones with pinacolborane can be achieved under catalyst-free and solvent-free conditions to provide the corresponding boronic esters in quant. yields. A large gram-scale hydroboration of acetophenone with HBpin under the same conditions was also performed to afford the alc. product in a high yield thus demonstrating the scalability of the newly developed simple protocol. In the part of experimental materials, we found many familiar compounds, such as 1-Thiophen-2-yl-ethanone(cas: 88-15-3Recommanded Product: 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Recommanded Product: 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Product Details of 88-15-3In 2021 ,《Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands》 appeared in Catalysis Communications. The author of the article were Wang, Mengna; Zhang, Ling; Sun, Hao; Chen, Qian; Jiang, Jian; Li, Linlin; Zhang, Lin; Li, Li; Li, Chun. The article conveys some information:

The Ru-catalyzed asym. hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcs. in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asym. hydrogenation was proposed and verified by NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Product Details of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Product Details of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application In Synthesis of 1-Thiophen-2-yl-ethanoneIn 2019 ,《Divergent synthesis and evaluation of the in vitro cytotoxicity profiles of 3,4-ethylenedioxythiophenyl-2-propen-1-one analogues》 was published in ChemMedChem. The article was written by Karunakaran, Jayachandran; Dhatchana Moorthy, Nachiappan; Chowdhury, Somenath Roy; Iqbal, Saleem; Majumder, Hemanta K.; Gunasekaran, Krishnasamy; Vellaichamy, Elangovan; Mohanakrishnan, Arasambattu K.. The article contains the following contents:

A new series of thiophene derivatives I [R = (E)-3,4,5-tri-MeOC6H2CH=CHC(O), 3,4,5-tri-MeOC6H2C(O), 2-amino-6-(4-bromophenyl)pyrimidin-4-yl, etc.; R1 = H, Me; R2 = H; R1R2 = O(CH2)2O; R3 = H, 2-thienyl] were synthesized by condensation reaction and evaluated for their in vitro cytotoxicity effects against five human cancer cell lines. Preliminary structure-activity relationships of compounds I were also established. The 3,4-ethylenedioxythiophene (EDOT)-appended enones demonstrated significant cytotoxicity against human cancer cell lines. The most active compound I [R = (E)-3,4,5-tri-MeOC6H2C(O)CH=CH; R1R2 = O(CH2)2O; R3 = H] (GI50=110 nM), severely inhibited clonogenic potential of cancer cells and induced cell-cycle arrest in G2/M phase and caused an accumulation of HCT116 colon cancer cells with >4 N DNA content. Also, compound I [R = (E)-3,4,5-tri-MeOC6H2C(O)CH=CH; R1R2 = O(CH2)2O; R3 = H] exhibited weak inhibition of the enzymic activity of human topoisomerase I. Mol. docking studies indicated preferential binding of the compounds I to ATP-binding pocket of human checkpoint 2 kinase (Chk2) catalytic domain, thus, identifying a novel diaryl 2-propenone chemotype for development of potent inhibitors of Chk2. The results came from multiple reactions, including the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Application In Synthesis of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Application In Synthesis of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem