The author of 《One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8, and Formamide》 were Shi, Taoda; Kaneko, Lynn; Sandino, Michael; Busse, Ryan; Zhang, Mae; Mason, Damian; Machulis, Jason; Ambrose, Andrew J.; Zhang, Donna D.; Chapman, Eli. And the article was published in ACS Sustainable Chemistry & Engineering in 2019. COA of Formula: C6H6OS The author mentioned the following in the article:
Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatog. steps. We herein report a green approach to the synthesis of this pharmacol. important class of compounds, e.g. I, via a catalytic four-component reaction using a ketone, Et cyanoacetate, S8, and formamide. The reported reaction is characterized by step economy, reduced catalyst loading, and easy purification In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3COA of Formula: C6H6OS)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. COA of Formula: C6H6OS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem