Prugh, John D.; Hartman, George D.; Mallorga, Pierre J.; McKeever, Brian M.; Michelson, Stuart R.; Murcko, Mark A.; Schwam, Harvey; Smith, Robert L.; Sondey, John M. published an article in Journal of Medicinal Chemistry. The title of the article was 《New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides》.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane The author mentioned the following in the article:
A series of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides I (R = substituted aminomethyl, oxazinylmethyl, thiazinylmethyl, substituted carbamoyl) and thieno[3,2-b]thiophene-2-sulfonamides II (R1 = Me2CHCH2, Me, MeOCH2CH2, R2 = H, MeOCH2CH2) was prepared and evaluated for topical ocular hypotensive activity in glaucoma models. The 5-substituents were varied to maximize both inhibitory potency against carbonic anhydrase and water solubility At the same time, these substituents were varied in order to obtain compounds with the appropriate pKa to minimize pigment binding in the iris. All of these variables were optimized best in compound I.HCl (R = NR3R4, R3 = MeOCH2CH2OCH2CH2, R4 = MeOCH2CH2).2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane) was used in this study.
2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem