《Assessment of headspace solid-phase microextraction (HS-SPME) for control of asymmetric bioreduction of ketones by Alternaria alternata》 was published in Biocatalysis and Biotransformation in 2020. These research results belong to Ogorek, Rafal; Jarosz, Bogdan. Synthetic Route of C6H6OS The article mentions the following:
The aim of this study was to assess the effectiveness of headspace solid-phase microextraction (HS-SPME) compared to liquid-liquid extractions using with methylene chloride (CH2Cl2) for control of fungal biotransformation of ketones of varying volatility. The proposed method was successfully applied. The best way to extract all the components of the mixture (alcs., aldehydes) in quantities similar to the extraction of methylene chloride was the use of fibers coated with a combination of nonpolar material. SPME fiber assembly polydimethylsiloxane/divinylbenzene (PDMS/DVB) was most suitable for the extraction of the products mixture obtained after biotransformation of acetylcyclohexane and acetophenone. On the other hand, the best results were obtained for 2-acetylthiophene, α,α,α-trifluoroacetophenone and their derivatives using divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber. In addition, our study showed that Alternaria alternata is a good biocatalyst for bioreduction of ketones to alcs. according to Prelogs rule. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem