《Exploration of Mesyl Chloride in a One Pot Conversion of Carboxylic Acids to Ketones》 was written by Mekonnen, Habtamu Gelaw; Sahoo, Debasis; Jana, Samaresh; Maji, Sanjoy Kumar. Category: benzothiophene And the article was included in Current Organocatalysis in 2020. The article conveys some information:
A simple and convenient one-pot methodol. for the synthesis of ketones R1C(O)R2 [R1 = Ph, 4-ClC6H4, 3,5-di-MeOC6H3, 2-furyl, 2-thienyl; R2 = Me, n-Bu] from carboxylic acids was developed. A carboxylic acid was converted to a mixed anhydride using mesyl chloride in the presence of a base. This mixed anhydride was then reacted with a suitable organometallic reagent at -20°C to obtain the desired ketone. Under the optimized reaction conditions, various aromatic and heteroaromatic carboxylic acids were converted to the corresponding ketones using organolithium and organomagnesium reagents with short reaction times. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Category: benzothiophene) was used in this study.
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem