The author of 《Palladium-Catalyzed C-H Arylation of Aliphatic and Aromatic Ketones using Dipeptide Transient Directing Groups》 were Cheng, Yaohang; Zheng, Jie; Tian, Chao; He, Yuhang; Zhang, Cong; Tan, Qi; An, Guanghui; Li, Guangming. And the article was published in Asian Journal of Organic Chemistry in 2019. Computed Properties of C6H6OS The author mentioned the following in the article:
Transition metal-catalyzed C-H bond functionalization is one of the most efficient tactics for diversification of ketones, e.g., 1-tetralone. Palladium-catalyzed C-H arylation of aliphatic and aromatic ketones has been achieved by utilizing an inexpensive dipeptide as a transient directing group. The tridentate coordination used in this reaction enhances the reactivity of the substrates and allows reduction of the loading of the directing group compounds to 20%. This approach allows rapid arylation of complex natural products, medicinal-chem.-related scaffolds, and even remote C(sp2)-H bonds. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Computed Properties of C6H6OS)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Computed Properties of C6H6OS
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem