Day: October 14, 2022

《Palladium-carbene catalyzed direct arylation of five-membered heteroaromatics》 was written by Kaloglu, Murat; Kaloglu, Nazan; Yildirim, Ilkay; Ozdemir, Namik; Ozdemir, Ismail. Computed Properties of C6H6OS And the article was included in Journal of Molecular Structure in 2020. The article conveys some information:

In this study, PEPPSI-type, (PEPPSI = Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation), new Pd-catalysts with N-heterocyclic carbene ligand I [R1 = Ph, 4-MeC6H4, 2,4,6-(Me)3C6H2, etc.; R2 = nBu, 3-MeOC6H4; X = Cl, Br] were synthesized and used as catalysts in the synthesis of bi(hetero)arenes R3-R4 [R3 = 5-acetyl-2-thienyl, furan-2-carbonyl, 4,5-dimethyl-thiazolyl; R4 = Ph, 4-MeC6H4, 3-quinolyl, etc.] by direct arylation process. The structures of complexes I were elucidated by different spectroscopic and anal. techniques such as NMR, FT-IR and elemental anal. The more detailed structural characterization of one of the complexes I [R1 = 4-MeC6H4; R2 = 3-MeOC6H4; X = Br] was determined by single-crystal X-ray diffraction study. Complexes I were used as effective catalysts in the direct arylation of five-membered heteroaromatics such as thiophene, furan and thiazole derivatives with aryl bromides in the presence of 1 mol% of catalyst loading and successful results were obtained. In the experimental materials used by the author, we found 1-Thiophen-2-yl-ethanone(cas: 88-15-3Computed Properties of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Computed Properties of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Lewis Base-Catalyzed Enantioselective Conjugate Reduction of β,β-Disubstituted α,β-Unsaturated Ketones with Trichlorosilane: E/Z-Isomerization, Regioselectivity, and Synthetic Applications》 were Sugiura, Masaharu; Ashikari, Yasuhiko; Takahashi, Yuka; Yamaguchi, Koki; Kotani, Shunsuke; Nakajima, Makoto. And the article was published in Journal of Organic Chemistry in 2019. Synthetic Route of C6H6OS The author mentioned the following in the article:

The chiral bisphosphine dioxide-catalyzed asym. conjugate reduction of acyclic β,β-disubstituted α,β-unsaturated ketones with trichlorosilane affords saturated ketones having a stereogenic carbon center at the carbonyl β-position with high enantioselectivities. Because the E/Z-isomerizations of enone substrates occur concomitantly, reduction products with the same absolute configurations are obtained from either (E)- or (Z)-enones. Conjugate reduction is accelerated in the presence of an electron-rich aryl group at the β-position of the enone owing to its carbocation-stabilizing ability. Computational studies were also conducted in order to elucidate the origin of the observed enantioselectivity. The regio- and enantioselective reductions of dienones were realized and applied to the syntheses of ar-turmerone, turmeronol A, mutisianthol, and jungianol, which are optically active sesquiterpenes. The experimental process involved the reaction of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Synthetic Route of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Preparation of optically active 2-(or 3)(p-tolylsulfinyl)-3(or 2)furyl- or thienylcarboxaldehydes》 was written by Girodier, Laurent D.; Maignan, Christian S.; Rouessac, Francis P.. Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane And the article was included in Tetrahedron: Asymmetry on August 31 ,1995. The article conveys some information:

The preparation of the four enantiomerically pure title compounds is described by reaction of (1)-(-)-Ss-menthyl-p-toluenesulfinate on furan or thiophene precursors. The experimental process involved the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Exploration of Mesyl Chloride in a One Pot Conversion of Carboxylic Acids to Ketones》 was written by Mekonnen, Habtamu Gelaw; Sahoo, Debasis; Jana, Samaresh; Maji, Sanjoy Kumar. Category: benzothiophene And the article was included in Current Organocatalysis in 2020. The article conveys some information:

A simple and convenient one-pot methodol. for the synthesis of ketones R1C(O)R2 [R1 = Ph, 4-ClC6H4, 3,5-di-MeOC6H3, 2-furyl, 2-thienyl; R2 = Me, n-Bu] from carboxylic acids was developed. A carboxylic acid was converted to a mixed anhydride using mesyl chloride in the presence of a base. This mixed anhydride was then reacted with a suitable organometallic reagent at -20°C to obtain the desired ketone. Under the optimized reaction conditions, various aromatic and heteroaromatic carboxylic acids were converted to the corresponding ketones using organolithium and organomagnesium reagents with short reaction times. In addition to this study using 1-Thiophen-2-yl-ethanone, there are many other studies that have used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Category: benzothiophene) was used in this study.

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Well-defined PEPPSI-themed palladium-NHC complexes: synthesis, and catalytic application in the direct arylation of heteroarenes》 was written by Kaloglu, Murat; Gurbuz, Nevin; Yildirim, Ilkay; Ozdemir, Namik; Ozdemir, Ismail. Related Products of 88-15-3 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

In this study, a series of benzimidazolium salts were synthesized as unsym. N-heterocyclic carbene (NHC) precursors. Benzimidazolium salts were used for synthesis of the PEPPSI (pyridine enhanced precatalyst preparation stabilization and initiation)-themed, six new Pd-complexes I [R = 4-MeOC6H4CH2, 4-t-BuC6H4, 2,4,6-(Me)3C6H2, etc.; X = Cl, Br]. The structures of all compounds were characterized by various spectroscopic techniques such as 1H NMR, 13C NMR and FT-IR. The more detailed structural characterization of four of the complexes was determined by single crystal X ray diffraction study. The catalytic activities of all Pd-complexes were evaluated in the direct arylation of the 2-acetylfuran and 2-acetylthiophene with aryl bromides in the presence of 1 mol% catalyst loading to afford biaryls II [R1 = Ph, 4-MeC6H4, 4-CHOC6H4, etc.; Y = O,S]. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Related Products of 88-15-3)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Related Products of 88-15-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolaneOn May 31, 2000, Chen, H.-H.; Gross, S.; Liao, J.; McLaughlin, M.; Dean, T.; Sly, W. S.; May, J. A. published an article in Bioorganic & Medicinal Chemistry. The article was 《2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit》. The article mentions the following:

Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human carbonic anhydrase II, Ki<0.5 nM. Addnl., inhibition of recombinant human carbonic anhydrase IV was determined for selected compounds; these were shown to be moderate to potent inhibitors of this isoenzyme with IC50 values ranging from 4.25 to 73.6 nM. Of the compounds evaluated for their ability to lower intraocular pressure in naturally hypertensive Dutch-belted rabbits, several showed significant efficacy (>20% decrease) in this model following topical ocular administration. The experimental process involved the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Hibino, Satoshi; Kano, Shinzo; Mochizuki, Naoki; Sugino, Eiichi published their research in Journal of Organic Chemistry on December 14 ,1984. The article was titled 《A new route to the pyridine nucleus fused to some heterocycles》.Related Products of 13250-82-3 The article contains the following contents:

Thermal cyclization of the appropriate 1-aza-1,3,5-hexatriene systems (oximes) gave the thieno[3,2-c]pyridines I (R = H, Me, Ph) and the 5H-pyrido[4,3-b]indoles II (R, R1, R2 = CO2Me, H, Me; CO2Me, Me, Ph; H, Me, Ph). In the experiment, the researchers used 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Related Products of 13250-82-3)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Related Products of 13250-82-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Functionalization of SBA-15 mesoporous materials with 2-acetylthiophene for adsorption of Cr(III) ions》 was published in Microporous and Mesoporous Materials in 2020. These research results belong to Wu, Hongmei; Xiao, Yu; Guo, Yu; Miao, Shiju; Chen, Qiangqiang; Chen, Zan. Electric Literature of C6H6OS The article mentions the following:

SBA-15 mesoporous materials functionalized with 2-acetylthiophene-derived Schiff’s base denoted as A-SBA-15, were synthesized for removal of Cr(III) ions from aqueous solution The adsorbent materials were characterized by XRD, SEM, TEM, N2 adsorption-desorption, TGA, EDXS, FTIR, 13C CP-MASNMR and XPS. Tests were then performed to study the adsorption of Cr(III) ions onto A-SBA-15 in batch systems. The maximum adsorption capacity of A-SBA-15 (114.2 mg/g) for Cr(III) ions was much higher than that of the pure SBA-15 (15.6 mg/g). The kinetics anal. revealed that the adsorption process was well described by pseudo-second-order kinetic model. The Langmuir isotherm model was better fitted with the adsorption data for Cr(III) compared to the Freundlich isotherm model. Also, the Cr(III) adsorption onto A-SBA-15 is spontaneous, endothermic, and mainly chem. adsorption as shown by the study of various thermodn. parameters, such as, ΔG°, ΔH°, and ΔS°. The characterization of A-SBA-15 materials before and after adsorption of Cr(III) ions showed that the chem. combination of the organic groups on A-SBA-15 and Cr(III) ions through coordination bond. The as-prepared A-SBA-15 materials could be reused in 5 successive recycles without significantly decreasing its adsorption capacity. Also, 4 batches of A-SBA-15 prepared at different synthesis times have the similar adsorption capacity. Besides, the adsorbent showed good selective separation of Cr(III) ion in the presence of Cu(II), Zn(II) and Ni(II) ions. The good reproductivity, reusability and selectivity suggest that A-SBA-15 material can be used as a promising adsorbent for efficient removal of heavy metals from aqueous solution The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Electric Literature of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Electric Literature of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Assessment of headspace solid-phase microextraction (HS-SPME) for control of asymmetric bioreduction of ketones by Alternaria alternata》 was published in Biocatalysis and Biotransformation in 2020. These research results belong to Ogorek, Rafal; Jarosz, Bogdan. Synthetic Route of C6H6OS The article mentions the following:

The aim of this study was to assess the effectiveness of headspace solid-phase microextraction (HS-SPME) compared to liquid-liquid extractions using with methylene chloride (CH2Cl2) for control of fungal biotransformation of ketones of varying volatility. The proposed method was successfully applied. The best way to extract all the components of the mixture (alcs., aldehydes) in quantities similar to the extraction of methylene chloride was the use of fibers coated with a combination of nonpolar material. SPME fiber assembly polydimethylsiloxane/divinylbenzene (PDMS/DVB) was most suitable for the extraction of the products mixture obtained after biotransformation of acetylcyclohexane and acetophenone. On the other hand, the best results were obtained for 2-acetylthiophene, α,α,α-trifluoroacetophenone and their derivatives using divinylbenzene/carboxen/polydimethylsiloxane (DVB/CAR/PDMS) fiber. In addition, our study showed that Alternaria alternata is a good biocatalyst for bioreduction of ketones to alcs. according to Prelogs rule. In the experiment, the researchers used many compounds, for example, 1-Thiophen-2-yl-ethanone(cas: 88-15-3Synthetic Route of C6H6OS)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Synthetic Route of C6H6OS

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《One-Pot Transfer Hydrogenation Reductive Amination of Aldehydes and Ketones by Iridium Complexes “”on Water””》 was written by Ouyang, Lu; Xia, Yanping; Liao, Jianhua; Luo, Renshi. Safety of 1-Thiophen-2-yl-ethanone And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient and practical one-pot transfer hydrogenation reductive amination of aldehydes and ketones with amines has been developed by using iridium complexes as catalysts and formic acid as hydrogen source in aqueous solution, providing an environmentally friendly methodol. for the construction of a wide range of functionalized amine compounds in excellent yields (≈ 80%-95%). This effective methodol. can be scaled up to gram scale with 0.1 mol-% catalyst loading and also be employed in the synthesis of medical substances such as Meclizine. In the experiment, the researchers used 1-Thiophen-2-yl-ethanone(cas: 88-15-3Safety of 1-Thiophen-2-yl-ethanone)

1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Reflecting their high stabilities, thiophenes arise from many reactions involving sulfur sources and hydrocarbons, especially unsaturated ones. Thiophenes are classically prepared by the reaction of 1,4-diketones, diesters, or dicarboxylates with sulfidizing reagents such as P4S10 such as in the Paal-Knorr thiophene synthesis. Safety of 1-Thiophen-2-yl-ethanone

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem