In 2019,Journal of Heterocyclic Chemistry included an article by Shelke, Premchand B.; Mali, Suraj N.; Chaudhari, Hemchandra K.; Pratap, Amit P.. Application In Synthesis of 1-Thiophen-2-yl-ethanone. The article was titled 《Chitosan hydrochloride mediated efficient, green catalysis for the synthesis of perimidine derivatives》. The information in the text is summarized as follows:
Chitosan hydrochloride as biopolymer-based, renewable and recyclable heterogeneous catalyst was used for efficient one-pot synthesis of 2,3-dihydro-1H-perimidine derivatives I [R1 = H, Me, Et, Ph; R2 = Me, Ph, 2-furyl, etc.; R1R2 = (CH2)5] via reaction of naphthalene-1,8-diamine with various ketones. This newly developed greener methodol. provided a very simple and greener route for the synthesis of perimidines in short time with excellent yield.1-Thiophen-2-yl-ethanone(cas: 88-15-3Application In Synthesis of 1-Thiophen-2-yl-ethanone) was used in this study.
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Application In Synthesis of 1-Thiophen-2-yl-ethanone
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem