Sasane, Sachin A.; Husain, Mofazzal; Bhise, Nandu B.; Singh, Girij P.; Joseph, Alex; Shenoy, Gautham G. published their research in Organic Preparations and Procedures International in 2021. The article was titled 《An Improved Process for Synthesis of (S)-Duloxetine Hydrochloride Involving Enzymatic Asymmetric Carbonyl Reduction on a Novel Ketoamine》.Product Details of 88-15-3 The article contains the following contents:
A new ketoamine intermediate was synthesized and devised exptl. conditions to obtain 100% ee for the carbonyl reduction during the synthesis of (S)-duloxetine hydrochloride I using com. available ketoreductase enzymes. The experimental part of the paper was very detailed, including the reaction process of 1-Thiophen-2-yl-ethanone(cas: 88-15-3Product Details of 88-15-3)
1-Thiophen-2-yl-ethanone(cas: 88-15-3) belongs to thiophenes. Specialized thiophenes can be synthesized similarly using Lawesson’s reagent as the sulfidizing agent, or via the Gewald reaction, which involves the condensation of two esters in the presence of elemental sulfur. Another method is the Volhard–Erdmann cyclization. Product Details of 88-15-3
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem