In 1967,Acta Chemica Scandinavica (1947-1973) included an article by Gronowitz, Salo; Persson, Birgitta. Safety of 2-(Thiophen-3-yl)-1,3-dioxolane. The article was titled 《A convenient synthesis of thieno[2,3-b]thiophene》. The information in the text is summarized as follows:
Compound I (0.10 mole) in 30 ml. Et2O was treated dropwise with 89 ml. 1.2N BuLi in Et2O under N, the mixture refluxed 20 min., cooled in ice, 0.10 mole dry S added in small portions, the mixture refluxed 1 hr., cooled, 0.10 mole ClCH2CO2Me in 20 ml. Et2O added dropwise, and, after standing overnight, the mixture added to cold 2N HCl. The solution was extracted with Et2O, the extract dried, added dropwise to a solution of 6.9 g. Na in 200 ml. EtOH, the mixture refluxed 5 hrs., Et2O distilled, and the residue added to H2O and acidified to precipitate 94% II, m. 242-4° (AcOH). Crude II (9.2 g.), 5 g. Cu powder, and 100 ml. quinoline was heated carefully to 180° for 2 hrs. and to 225-30° for 24 hrs., the mixture distilled, the distillate acidified, and the insoluble oil distilled to give 78% title compound (III) b10 95°; picrate m. 135.5-6.5° (MeOH and EtOH). After reading the article, we found that the author used 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Safety of 2-(Thiophen-3-yl)-1,3-dioxolane)
2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Safety of 2-(Thiophen-3-yl)-1,3-dioxolane
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem