Month: April 2022

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hao, Er-Jun; Li, Gong-Xin; Liang, Yu-Ru; Xie, Ming-Sheng; Wang, Dong-Chao; Jiang, Xiao-Han; Cheng, Jia-Yi; Shi, Zhi-Xian; Wang, Yang; Guo, Hai-Ming researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).HPLC of Formula: 3395-91-3.They published the article 《Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo》 about this compound( cas:3395-91-3 ) in Journal of Medicinal Chemistry. Keywords: colon cancer drug discovery anticancer acyclic nucleoside synthesis chloropurinyldodecanol; structure activity antitumor acyclic nucleoside synthesis human apoptosis. We’ll tell you more about this compound (cas:3395-91-3).

In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro and in vivo. The structure-activity relationship (SAR) studies revealed that most target compounds inhibited the growth of colon cancer cells in vitro, of which (chloro-9H-purinyl)dodecanol I exhibited the most potent effect against the HCT-116 and SW480 cells with IC50 values of 0.89 and 1.15μM, resp. Furthermore, all of the (R)-configured acyclic nucleoside derivatives displayed more potent anticancer activity compared to their (S)-counterparts. Mechanistic studies revealed that compound I triggered apoptosis in the cancer cell lines via depolarization of the mitochondrial membrane and effectively inhibited colony formation. Importantly, I inhibited the growth of the SW480 xenograft in a mouse model with low systemic toxicity. These results indicated that acyclic nucleoside compounds are viable as potent and effective anticancer agents, and I may serve as a promising lead compound that merits further attention in future anticancer drug discovery.

Different reactions of this compound(Methyl 3-bromopropanoate)HPLC of Formula: 3395-91-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application of 3395-91-3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents. Author is Peng, Xiaopeng; Chen, Jingxuan; Li, Ling; Sun, Zhiqiang; Liu, Jin; Ren, Yichang; Huang, Junli; Chen, Jianjun.

Novel dual HDAC3/tubulin inhibitors were designed and efficiently synthesized by combining the pharmacophores of SMART (tubulin inhibitor) and MS-275 (HDAC inhibitor), among which compound 15c was found to be the most potent and balanced HDAC3/tubulin dual inhibitor with high HDAC3 activity (IC50 = 30 nM) and selectivity (SI > 1000) as well as excellent antiproliferative potency against various cancer cell lines, including an HDAC-resistant gastric cancer cell line (YCC3/7) with IC50 values in the range of 30-144 nM. Compound 15c inhibited B16-F10 cancer cell migration and colony formation. In addition, 15c demonstrated significant in vivo antitumor efficacy in a B16-F10 melanoma tumor model with a better TGI (70.00%, 10 mg/kg) than that of the combination of MS-275 and SMART. Finally, 15c presented a safe cardiotoxicity profile and did not cause nephro-/hepatotoxicity. Collectively, this work shows that compound 15c represents a novel tubulin/HDAC3 dual-targeting agent deserving further investigation as a potential anticancer agent.

Different reactions of this compound(Methyl 3-bromopropanoate)Application of 3395-91-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Product Details of 3395-91-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about The Synthesis of a Two-Photon Fluorescence Labelling Probe and its Immunochromatographic Strip for Rapid Diagnosis of COVID-19. Author is Huang, Chibao; Kang, Shuai; Yu, Fuxun; Wei, Zairong.

A two-photon fluorescence labeling probe (LP) was synthesized, and LP-Ag was obtained by LP labeling the N-protein antigen (Ag) of COVID-19. LP-Ag was made into an immunochromatog. strip. When a blood sample was added to the sample hole of the test card, it would move forward along the nitrocellulose (NC) film. If the sample contained IgM, the IgM bound to LP-Ag and formed an M line with the coated mouse anti-human IgM antibody, giving a pos. response to the presence of IgM of COVID-19. The sensitivity, specificity, and accuracy of the immunochromatog. strip based on the LP was compared with those of the nucleic acid detection method and the colloidal gold method, proving it to be much simpler than the nucleic acid detection method, which can greatly shorten the detection period, and to be much more stable than the colloidal gold method, which can overcome uncertainty. LP-Ag can be used to image lung tissue with COVID-19 by two-photon fluorescence microscopy (TFM).

Different reactions of this compound(Methyl 3-bromopropanoate)Product Details of 3395-91-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 3-bromopropanoate(SMILESS: O=C(OC)CCBr,cas:3395-91-3) is researched.Application of 3395-91-3. The article 《A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy》 in relation to this compound, is published in Chemical Science. Let’s take a look at the latest research on this compound (cas:3395-91-3).

The scarcity of efficient imaging technologies for precise cancer treatment greatly drives the development of new nanotheranostic based platforms that enable both diagnostic and therapeutic functions, together in a single formulation. Owing to the complicated physiol. microenvironment, nanosystems designed with the possibility of noninvasive real-time monitoring of therapeutic progression in the second near-IR channel (NIR-II, 1000-1700 nm) could substantially improve the current cancer therapies. Herein, we design a novel NIR-II theranostic nanoprobe, PSY (size ∼110 nm), by incorporating organoplatinum(II) metallacycles P1 and an organic NIR-II mol. dye, SY1030, into the FDA-approved polymer Pluronic F127. Preliminary in vitro and in vivo studies suggest that PSY is capable of being internalized into glioma U87MG-cells with no significant internalization in non-cancerous tissues. In addition, it shows excellent photostability and minimal background for real-time monitoring the process of therapy in the NIR-II region. Furthermore, in U87MG xenografts and orthotopic breast tumor, PSY demonstrat significantly improved anticancer efficacy compared to a clin. approved Pt(II)-based anticancer drug, cisplatin. The engineered nano-cocktail PSY offers a simple strategy for delivering the organoplatinum(II) macrocycle P1 and NIR-II fluorophore SY1030 as a cocktail of diagnostic and therapeutic functions and highlights its promising capacity for future cancer treatment.

The article 《A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy》 also mentions many details about this compound(3395-91-3)Category: benzothiophene, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Rational Design of a Multifunctional Molecular Dye with Single Dose and Laser for Efficiency NIR-II Fluorescence/Photoacoustic Imaging Guided Photothermal Therapy, published in 2019-10-01, which mentions a compound: 3395-91-3, Name is Methyl 3-bromopropanoate, Molecular C4H7BrO2, Application of 3395-91-3.

Multifunctional probes integrating accurate multi-diagnosis and efficient therapy hold great prospect in biomedical research. However, the sophisticated construction and difficulties in matching the ratios of doses and laser triggers of probes for each modality imaging and therapy are still hindered the extensive practice of multifunctional probes in biomedicine. We herein rational designed an organic dye SY1080 with intrinsic multifunction by both introducing 3,4-ethylenedioxy thiophene (EDOT) and the selenium containing acceptor unit into the backbone to balance the fluorescence brightness and emission wavelength. Under single dose and 808 nm laser irradiation conditions, SY1080 not only carried out NIR-II fluorescence/Photoacoustic imaging of real-time and noninvasive tumor delineation with excellent contrast, but also effectively ablated tumors with laser irradiation to perform PTT under the guidance of dual-modal imaging. These exciting results highlighted SY1080 as a multifunctional and universal phototheranostic platform for potential applications.

The article 《Rational Design of a Multifunctional Molecular Dye with Single Dose and Laser for Efficiency NIR-II Fluorescence/Photoacoustic Imaging Guided Photothermal Therapy》 also mentions many details about this compound(3395-91-3)Application of 3395-91-3, you can pay attention to it, because details determine success or failure

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Formula: C4H7BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about The Synthesis of a Two-Photon Fluorescence Labelling Probe and its Immunochromatographic Strip for Rapid Diagnosis of COVID-19. Author is Huang, Chibao; Kang, Shuai; Yu, Fuxun; Wei, Zairong.

A two-photon fluorescence labeling probe (LP) was synthesized, and LP-Ag was obtained by LP labeling the N-protein antigen (Ag) of COVID-19. LP-Ag was made into an immunochromatog. strip. When a blood sample was added to the sample hole of the test card, it would move forward along the nitrocellulose (NC) film. If the sample contained IgM, the IgM bound to LP-Ag and formed an M line with the coated mouse anti-human IgM antibody, giving a pos. response to the presence of IgM of COVID-19. The sensitivity, specificity, and accuracy of the immunochromatog. strip based on the LP was compared with those of the nucleic acid detection method and the colloidal gold method, proving it to be much simpler than the nucleic acid detection method, which can greatly shorten the detection period, and to be much more stable than the colloidal gold method, which can overcome uncertainty. LP-Ag can be used to image lung tissue with COVID-19 by two-photon fluorescence microscopy (TFM).

The article 《The Synthesis of a Two-Photon Fluorescence Labelling Probe and its Immunochromatographic Strip for Rapid Diagnosis of COVID-19》 also mentions many details about this compound(3395-91-3)Formula: C4H7BrO2, you can pay attention to it, because details determine success or failure

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3395-91-3, is researched, Molecular C4H7BrO2, about Byproducts formed During Thiol-Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?, the main research direction is thiol acrylate nucleophilic aprotic amine Michael reaction mechanism; click chemistry; density functional theory; nucleophiles; reaction mechanisms; thiol-Michael reactions.Reference of Methyl 3-bromopropanoate.

The nucleophile-initiated mechanism of thiol-Michael reactions naturally leads to the formation of undesired nucleophile byproducts. Three aza-Michael compounds representing nucleophile byproducts of thiol-acrylate reactions initiated by 4-dimethylaminopyridine (DMAP), 1-methylimidazole (MIM), and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) have been synthesized and their reactivity in the presence of thiolate has been investigated. Spectroscopic anal. shows that each nucleophile byproduct reacts with thiolate to produce a desired thiol-acrylate product along with liberated aprotic amines DMAP, MIM, or DBU, thus demonstrating that these byproducts are reactive rather than persistent. D. functional theor. computations support exptl. observations and predict that a β-elimination mechanism is favored for converting each nucleophile byproduct into a desired thiol-acrylate product, though an SN2 process can be competitive (i. e. within <2.5 kcal/mol) in less polar solvents. The article 《Byproducts formed During Thiol-Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?》 also mentions many details about this compound(3395-91-3)Reference of Methyl 3-bromopropanoate, you can pay attention to it, because details determine success or failure

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 3-bromopropanoate(SMILESS: O=C(OC)CCBr,cas:3395-91-3) is researched.Quality Control of Methyl 3-bromopropanoate. The article 《Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(IV) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism》 in relation to this compound, is published in Dalton Transactions. Let’s take a look at the latest research on this compound (cas:3395-91-3).

The design of novel platinum(IV) complexes with mitochondria injury competence, besides the DNA damage mechanism, is a promising way to develop new platinum drugs. Herein, dihydro-2-quinolone (DHQLO) as a mitocan was incorporated into the platinum(IV) system for the first time to prepare a new series of DHQLO platinum(IV) compounds Complex 1b could effectively inhibit the proliferation of tumor cells in vitro and in vivo. It accumulated at higher levels in both whole cells and DNA, and easily underwent intercellular reduction to release platinum(II) and DHQLO moieties. The released platinum(II) complex caused serious DNA damage by covalent conjunction with the DNA duplex, and remarkably increased the expression of the γ-H2AX protein. Moreover, 1b also caused serious mitochondria injury to induce mitochondrial membrane depolarization and increase ROS generation. Such actions upon DNA and mitochondria activate the p53 apoptotic pathway synergetically in tumor cells by upregulating the protein p53 and apoptotic proteins caspase9 and caspase3, which efficiently promoted the apoptotic death of tumor cells. Compound 1b with such synergic mechanism exhibited great potential in reversing cisplatin resistance and improving antitumor efficacies.

The article 《Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(IV) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism》 also mentions many details about this compound(3395-91-3)Reference of Methyl 3-bromopropanoate, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]) to get more information.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Quality Control of Methyl 3-bromopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery. Author is Zeng, Xiaodong; Xie, Liru; Chen, Deliang; Li, Shanshan; Nong, Jinxia; Wang, Bo; Tang, Lin; Li, Qianqian; Li, Yang; Deng, Zixin; Hong, Xuechuan; Wu, Mingfu; Xiao, Yuling.

A novel bright near-IR II (NIR-II, 1000-1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chem. induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

The article 《A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery》 also mentions many details about this compound(3395-91-3)Quality Control of Methyl 3-bromopropanoate, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 3-bromopropanoate(SMILESS: O=C(OC)CCBr,cas:3395-91-3) is researched.Formula: C44H69NP2. The article 《Byproducts formed During Thiol-Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?》 in relation to this compound, is published in ChemPlusChem. Let’s take a look at the latest research on this compound (cas:3395-91-3).

The nucleophile-initiated mechanism of thiol-Michael reactions naturally leads to the formation of undesired nucleophile byproducts. Three aza-Michael compounds representing nucleophile byproducts of thiol-acrylate reactions initiated by 4-dimethylaminopyridine (DMAP), 1-methylimidazole (MIM), and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) have been synthesized and their reactivity in the presence of thiolate has been investigated. Spectroscopic anal. shows that each nucleophile byproduct reacts with thiolate to produce a desired thiol-acrylate product along with liberated aprotic amines DMAP, MIM, or DBU, thus demonstrating that these byproducts are reactive rather than persistent. D. functional theor. computations support exptl. observations and predict that a β-elimination mechanism is favored for converting each nucleophile byproduct into a desired thiol-acrylate product, though an SN2 process can be competitive (i. e. within <2.5 kcal/mol) in less polar solvents. The article 《Byproducts formed During Thiol-Acrylate Reactions Promoted by Nucleophilic Aprotic Amines: Persistent or Reactive?》 also mentions many details about this compound(3395-91-3)SDS of cas: 3395-91-3, you can pay attention to it, because details determine success or failure

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem