An update on the compound challenge: 71856-54-7

《Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile)Reference of 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Harden, Fiona A.; Quinn, Ronald J.; Scammells, Peter J. researched the compound: 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile( cas:71856-54-7 ).Reference of 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile.They published the article 《Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine》 about this compound( cas:71856-54-7 ) in Journal of Medicinal Chemistry. Keywords: methylisoguanosine analog pyrazolopyrimidine; aminoalkylarylpyrazolopyrimidinone preparation adenosine receptor affinity. We’ll tell you more about this compound (cas:71856-54-7).

Two series of pyrazolo[3,4-d]pyrimidine analogs I (R = Ph, substituted Ph; R1 = Me; R = Ph, R1 = Et, Pr, Bu, Ph; R = 3-ClC6H4, R1 = Et, Pr, Bu) of 1-methylisoguanosine have been synthesized. All I were tested for A1 adenosine receptor affinity by using a (R)-{3H}-N6-(phenylisopropyl)adenosine binding assay. The 3-chlorophenyl group showed the greatest activity in the N1-position and the Bu group produced the greatest activity in the N5-position. Combination of the best substituent in each of these positions enhanced the overall activity. The most potent compound was I (R = 3-C6H4Cl, R1 = Bu) (II) with an IC50 of 6.4 × 10-6M. Selectivity at the receptor subclasses was examined by performing an A2 adenosine receptor affinity assay with [3H]CGS 21680. This series of compounds were slightly less potent at A2 receptors. II was the most potent compound with an IC50 of 19.2 × 10-6M.

《Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile)Reference of 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem