Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Proceedings of the National Academy of Sciences of the United States of America called Melanin-dot-mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy, Author is Sun, Yue; Ding, Feng; Chen, Zhao; Zhang, Ruiping; Li, Chonglu; Xu, Yuling; Zhang, Yi; Ni, Ruidong; Li, Xiaopeng; Yang, Guangfu; Sun, Yao; Stang, Peter J., which mentions a compound: 3395-91-3, SMILESS is O=C(OC)CCBr, Molecular C4H7BrO2, Formula: C4H7BrO2.
Discrete Pt(II) metallacycles have potential applications in biomedicine. Herein, we engineered a dual-modal imaging and chemo-photothermal therapeutic nano-agent 1 that incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-IR channel [NIR-II]) into multifunctional melanin dots with photoacoustic signal and photothermal features. Nano-agent 1 has a good solubility, biocompatibility, and stability in vivo. Both photoacoustic imaging and NIR-II imaging in vivo confirmed that 1 can effectively accumulate at tumor sites with good signal-to-background ratio and favorable distribution. Guided by precise dual-modal imaging, nano-agent 1 exhibits a superior antitumor performance and less severe side effects compared with a single treatment because of the high efficiency of the chemo-photothermal synergistic therapy. This study shows that nano-agent 1 provides a promising multifunctional theranostic platform for potential applications in biomedicine.
Different reactions of this compound(Methyl 3-bromopropanoate)Formula: C4H7BrO2 require different conditions, so the reaction conditions are very important.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem