In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine, published in 1991-09-30, which mentions a compound: 71856-54-7, mainly applied to methylisoguanosine analog pyrazolopyrimidine; aminoalkylarylpyrazolopyrimidinone preparation adenosine receptor affinity, Application In Synthesis of 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile.
Two series of pyrazolo[3,4-d]pyrimidine analogs I (R = Ph, substituted Ph; R1 = Me; R = Ph, R1 = Et, Pr, Bu, Ph; R = 3-ClC6H4, R1 = Et, Pr, Bu) of 1-methylisoguanosine have been synthesized. All I were tested for A1 adenosine receptor affinity by using a (R)-{3H}-N6-(phenylisopropyl)adenosine binding assay. The 3-chlorophenyl group showed the greatest activity in the N1-position and the Bu group produced the greatest activity in the N5-position. Combination of the best substituent in each of these positions enhanced the overall activity. The most potent compound was I (R = 3-C6H4Cl, R1 = Bu) (II) with an IC50 of 6.4 × 10-6M. Selectivity at the receptor subclasses was examined by performing an A2 adenosine receptor affinity assay with [3H]CGS 21680. This series of compounds were slightly less potent at A2 receptors. II was the most potent compound with an IC50 of 19.2 × 10-6M.
After consulting a lot of data, we found that this compound(71856-54-7)Application In Synthesis of 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem