Related Products of 254905-58-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, is researched, Molecular C13H24N2O3, CAS is 254905-58-3, about Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations. Author is de la Fuente Revenga, Mario; Balle, Thomas; Jensen, Anders A.; Froelund, Bente.
Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.
Although many compounds look similar to this compound(254905-58-3)Related Products of 254905-58-3, numerous studies have shown that this compound(SMILES:O=C(N1CCC(C(N(C)C)=O)CC1)OC(C)(C)C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem