Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 3395-91-3, is researched, Molecular C4H7BrO2, about Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase, the main research direction is tetrazole derivative LYS 006 preparation LTA4H inhibitor antiinflammatory activity.Synthetic Route of C4H7BrO2.
The cytosolic metalloenzyme leukotriene A4 hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B4 (LTB4). Preclin. studies have validated this enzyme as an attractive drug target in chronic inflammatory diseases. Despite several attempts, no LTA4H inhibitor has reached the market, yet. Herein, we disclose the discovery and preclin. profile of LYS006 (I), a highly potent and selective LTA4H inhibitor. A focused fragment screen identified hits that could be cocrystd. with LTA4H and inspired a fragment merging. Further optimization led to chiral amino acids and ultimately to LYS006, a picomolar LTA4H inhibitor with exquisite whole blood potency and long-lasting pharmacodynamic effects. Due to its high selectivity and its ability to fully suppress LTB4 generation at low exposures in vivo, LYS006 has the potential for a best-in-class LTA4H inhibitor and is currently investigated in phase II clin. trials in inflammatory acne, hidradenitis suppurativa, ulcerative colitis, and NASH.
Although many compounds look similar to this compound(3395-91-3)Synthetic Route of C4H7BrO2, numerous studies have shown that this compound(SMILES:O=C(OC)CCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem