Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Reductive sp3-sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals.HPLC of Formula: 3395-91-3.
Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp3 character of mols. enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp3-sp2 cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with a broad range of primary and secondary alkyl halide coupling partners.
Although many compounds look similar to this compound(3395-91-3)HPLC of Formula: 3395-91-3, numerous studies have shown that this compound(SMILES:O=C(OC)CCBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem