de la Fuente Revenga, Mario; Balle, Thomas; Jensen, Anders A.; Froelund, Bente published the article 《Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations》. Keywords: carbamoylcholine homolog pharmacol neuron nicotinic receptor ligand; Acetylcholine; Agonist; Conformational restriction; Docking; Nicotinic acetylcholine receptor.They researched the compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate( cas:254905-58-3 ).Safety of tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:254905-58-3) here.
Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.
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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem