Cao, Jie; Chi, Jinnan; Xia, Junfei; Zhang, Yanru; Han, Shangcong; Sun, Yong published the article 《Iodinated Cyanine Dyes for Fast Near-Infrared-Guided Deep Tissue Synergistic Phototherapy》. Keywords: iodinated cyanine dye NIR phototherapy photodynamic therapy; Iodinated cyanine dyes; NIR imaging; enhanced ROS production; photodynamic therapy; photothermal therapy.They researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).Application of 3395-91-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3395-91-3) here.
Phototheranostics, which combines deep tissue imaging and phototherapy [photodynamic therapy (PDT) and/or photothermal therapy (PTT)] via light irradiation, is a promising strategy to treat tumors. Near-IR (NIR) cyanine dyes are researched as potential phototheranostics reagents for their excellent photophys. properties. However, the low singlet oxygen generation efficiency of cyanine dyes often leads to inadequate therapeutic efficacy for tumors. Herein, we modified an indocyanine green derivative Cy7 with heavy atom iodine to form a novel NIR dye CyI to improve the reactive oxygen species (ROS) production and heat generation while, at the same time, maintain their fluorescence characteristics for in vivo noninvasive imaging. More importantly, in vitro and in vivo therapeutic results illustrated that CyI could quickly and simultaneously generate enhanced ROS and heat to induce more cancer cell apoptosis and higher inhibition rates in deep HepG2 tumors than other noniodinated NIR dyes upon NIR irradiation Besides, low toxicity of the resulted iodinated NIR dyes was confirmed by in vivo biodistribution and acute toxicity. Results indicate that this low toxic NIR dye could be an ideal phototheranostics agent for deep tumor treatments. Our study presents a novel approach to achieve the fast-synergistic PDT/PTT treatment in deep tissues.
In addition to the literature in the link below, there is a lot of literature about this compound(Methyl 3-bromopropanoate)Application of 3395-91-3, illustrating the importance and wide applicability of this compound(3395-91-3).
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem