Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 254905-58-3, is researched, SMILESS is O=C(N1CCC(C(N(C)C)=O)CC1)OC(C)(C)C, Molecular C13H24N2O3Journal, Article, European Journal of Medicinal Chemistry called The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency, Author is Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet, the main research direction is growth hormone secretagogue structure activity C terminal conformation.Application of 254905-58-3.
In order to obtain more potent growth hormone secretagogues, a comparison of ipamorelin and NN703 suggested the addition of a polar group at the C-terminus of NN703. A study was conducted using constrained amines for this purpose. Here, substituted 4-piperidinylamino- and 4-dimethylaminopiperidino-substituents were found to give the most active compounds A replacement of the 4-dimethylaminopiperidino-substituent with 4-hydroxypiperidino resulted in a series of compounds, which showed in vitro activity with EC50 values in the low nanomolar range, and favorable kinetic properties, such as 40% oral bioavailability. The most promising compound was also tested in a swine in vivo model, resulting in a growth hormone level with a Cmax of over 40 ng mL-1.
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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem