New downstream synthetic route of 3395-91-3

There is still a lot of research devoted to this compound(SMILES：O=C(OC)CCBr)HPLC of Formula: 3395-91-3, and with the development of science, more effects of this compound(3395-91-3) can be discovered.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Greed, Stephanie; Briggs, Edward L.; Idiris, Fahima I. M.; White, Andrew J. P.; Luecking, Ulrich; Bull, James A. researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).HPLC of Formula: 3395-91-3.They published the article 《Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific Sulfur-Fluorine Exchange (SuFEx) Reaction》 about this compound( cas:3395-91-3 ) in Chemistry – A European Journal. Keywords: enantioenriched sulfonimidoyl fluoride sulfonimidamide preparation stereospecific SuFEx; SuFEx reactions; chirality; sulfonimidamides; sulfur; synthetic methods. We’ll tell you more about this compound (cas:3395-91-3).

Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for addnl. directional interactions. Here the authors present the first modular enantioselective synthesis of sulfonimidamides, including the first stereoselective synthesis of enantioenriched sulfonimidoyl fluorides, and studies on their reactivity. A new route to sulfonimidoyl fluorides is presented from solid bench-stable, N-Boc-sulfinamide salt building blocks. Enantioenriched arylsulfonimidoyl fluorides are shown to be readily racemized by fluoride ions. Conditions are developed, which trap fluoride and enable the stereospecific reaction of sulfonimidoyl fluorides with primary and secondary amines (100% es) generating sulfonimidamides with up to 99% ee. Aryl and alkyl sulfonimidoyl fluoride reagents are suitable for mild late stage functionalization reactions, exemplified by coupling with a selection of complex amines in marketed drugs.

There is still a lot of research devoted to this compound(SMILES：O=C(OC)CCBr)HPLC of Formula: 3395-91-3, and with the development of science, more effects of this compound(3395-91-3) can be discovered.

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem