The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of Highly Enantioenriched Sulfonimidoyl Fluorides and Sulfonimidamides by Stereospecific Sulfur-Fluorine Exchange (SuFEx) Reaction》. Authors are Greed, Stephanie; Briggs, Edward L.; Idiris, Fahima I. M.; White, Andrew J. P.; Luecking, Ulrich; Bull, James A..The article about the compound:Methyl 3-bromopropanoatecas:3395-91-3,SMILESS:O=C(OC)CCBr).Application of 3395-91-3. Through the article, more information about this compound (cas:3395-91-3) is conveyed.
Sulfonimidamides present exciting opportunities as chiral isosteres of sulfonamides, with potential for addnl. directional interactions. Here the authors present the first modular enantioselective synthesis of sulfonimidamides, including the first stereoselective synthesis of enantioenriched sulfonimidoyl fluorides, and studies on their reactivity. A new route to sulfonimidoyl fluorides is presented from solid bench-stable, N-Boc-sulfinamide salt building blocks. Enantioenriched arylsulfonimidoyl fluorides are shown to be readily racemized by fluoride ions. Conditions are developed, which trap fluoride and enable the stereospecific reaction of sulfonimidoyl fluorides with primary and secondary amines (100% es) generating sulfonimidamides with up to 99% ee. Aryl and alkyl sulfonimidoyl fluoride reagents are suitable for mild late stage functionalization reactions, exemplified by coupling with a selection of complex amines in marketed drugs.
There is still a lot of research devoted to this compound(SMILES：O=C(OC)CCBr)Application of 3395-91-3, and with the development of science, more effects of this compound(3395-91-3) can be discovered.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem