Safety of Methyl 3-bromopropanoate. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo. Author is Hao, Er-Jun; Li, Gong-Xin; Liang, Yu-Ru; Xie, Ming-Sheng; Wang, Dong-Chao; Jiang, Xiao-Han; Cheng, Jia-Yi; Shi, Zhi-Xian; Wang, Yang; Guo, Hai-Ming.
In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro and in vivo. The structure-activity relationship (SAR) studies revealed that most target compounds inhibited the growth of colon cancer cells in vitro, of which (chloro-9H-purinyl)dodecanol I exhibited the most potent effect against the HCT-116 and SW480 cells with IC50 values of 0.89 and 1.15μM, resp. Furthermore, all of the (R)-configured acyclic nucleoside derivatives displayed more potent anticancer activity compared to their (S)-counterparts. Mechanistic studies revealed that compound I triggered apoptosis in the cancer cell lines via depolarization of the mitochondrial membrane and effectively inhibited colony formation. Importantly, I inhibited the growth of the SW480 xenograft in a mouse model with low systemic toxicity. These results indicated that acyclic nucleoside compounds are viable as potent and effective anticancer agents, and I may serve as a promising lead compound that merits further attention in future anticancer drug discovery.
There is still a lot of research devoted to this compound(SMILES：O=C(OC)CCBr)Safety of Methyl 3-bromopropanoate, and with the development of science, more effects of this compound(3395-91-3) can be discovered.
Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem