Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment. Quality Control of 2-Bromobenzo[b]thiophene
Copper/palladium-catalyzed multicomponent cyclization reactions, which combine 2-gem-dibromovinyl aryl selenides with a nucleophilic source, were applied to the synthesis of 2-substituted benzo[b]selenophenes. A systematic study of the cyclization system revealed that the mutual action between copper and palladium salts is essential for the formation of products in good yields, avoiding the formation of hydrogenated benzo[b]selenophenes. The versatility of 2-bromobenzo[b]selenophenes was also studied by palladium-catalyzed reactions with boronic acids, Grignard reagents and methyl acrylate affording the cross-coupled products in good yields. In addition, the reaction of 2-bromobenzo[b]selenophene towards halogen-lithium exchange reactions followed by the addition of aldehyde afforded the corresponding secondary alcohol. (Figure presented.).
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’molecules. Read on for other articles about 5394-13-8
Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem