Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. Safety of 5-Bromobenzothiophene
A concise synthesis of phenanthridine derivatives is achieved by an iridium-catalyzed direct fusion of oxime ethers and heteroarenes, which is a successful example of a cascade C-H/C-H cross-coupling/cyclization strategy for polycyclic heteroaromatic synthesis. By subtle tuning of the reaction conditions, both benzo- and simple five-membered heteroarenes are suitable substrates under similar but different conditions. The key is the right choice of a silver salt. The detailed mechanistic study discloses that the first C-H/C-H cross-coupling step involves an [IrII]-[IrIV] catalytic cycle, which needs Ag2O as the oxidant. For the second cyclization step, a radical process takes control in the reactions of benzoheteroarenes and Ag2O is required; however, a C-H cyclization functions in the reactions of simple five-membered heteroarenes involving an [IrI]-[IrIII] catalytic cycle, and AgTFA is necessary.
We very much hope you enjoy reading the articles and that you will join us to present your own research about 4923-87-9, Safety of 5-Bromobenzothiophene
Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem