Application of 19301-35-0, Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. In a article, 19301-35-0, molcular formula is C8H6OS, introducing its new discovery.
New heteroaryl HIV-protease inhibitors bearing a carbamoyl spacer were synthesized in few steps and high yield, from commercially available homochiral epoxides. Different substitution patterns were introduced onto a given isopropanoyl-sulfonamide core that can have either H or benzyl group. The in vitro inhibition activity against recombinant protease showed a general beneficial effect of both carbamoyl moiety and the benzyl group, ranging the IC50 values between 11 and 0.6 nM. In particular, benzofuryl and indolyl derivatives showed IC50 values among the best for such structurally simple inhibitors. Docking analysis allowed to identify the favorable situation of such derivatives in terms of number of interactions in the active site, supporting the experimental results. The inhibition activity was also confirmed in HEK293 mammalian cells and was maintained against protease mutants. Furthermore, the metabolic stability was comparable with that of the commercially available inhibitors.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Application of 19301-35-0, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about Application of 19301-35-0
Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem