Day: August 19, 2021

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. name: 2,3-Dibromobenzo[b]thiophene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 6287-82-7, Name is 2,3-Dibromobenzo[b]thiophene, molecular formula is C8H4Br2S

There are provided a heteroacene derivative having an excellent oxidation resistance and capable of forming a semiconductor active phase by a coating process, and an oxidation-resistant organic semiconductor material using the same, as well as an organic thin film. [Means for Resolution] heteroacene derivative represented by the formula (1) is obtained by tetrametalation of a tetrahaloterphenyl derivative with a metalation agent and subsequent treatment of the resulting compound with reaction agents: wherein the substituents R1 to R4 are the same or different and each represents a hydrogen atom, a fluorine atom, a chlorine atom, an aryl group having 4 to 30 carbon atoms, an alkyl group having 3 to 20 carbon atoms, or a halogenated alkyl group having 1 to 20 carbon atoms; T1 and T2 are the same or different and each represents sulfur, selenium, tellurium, oxygen, phosphorus, boron, or aluminum; 1 and m each is an integer of 0 or 1; and rings A and B are the same or different and each has a structure represented by the following formulae (A-1) or (A-2).

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. The reactant in an enzyme-catalyzed reaction is called a substrate. Product Details of 63675-74-1, C16H14O2S. A document type is Article, introducing its new discovery., Product Details of 63675-74-1

This article reports the efficient preparation of a series of unsymmetrically substituted thioethers through a two-step procedure consisting of an initial metal-free C?H sulfenylation of electron-rich (hetero)arenes with newly prepared succinylthioimidazolium salts. Subsequent reaction of the arylthioimidazolium intermediates with Grignard reagents afford the desired thioethers. The synthetic protocol described is modular, scalable, and high yielding, and provides access to sulfides that are not easy to obtain through the existing methodologies. Importantly, no prefunctionalization of the initial (hetero)arene is required.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthetic Route of 310466-38-7, New research progress on 310466-38-7 in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In a article, 310466-38-7, molcular formula is C8H5FS, introducing its new discovery.

Novel nonsteroidal C(17,20)-lyase inhibitors were synthesized using de novo design based on its substrate, 17 alpha-hydroxypregnenolone, and several compounds exhibited potent C(17,20)-lyase inhibition. However, in vivo activities were found to be short-lasting, and in order to improve the duration of action, a series of benzothiophene derivatives were evaluated. As a result, compounds 9h, (S)-9i, and 9k with nanomolar enzyme inhibition (IC(50)=4-9 nM) and 9e (IC(50)=27 nM) were identified to have powerful in vivo efficacy with extended duration of action. The key structural determinants for the in vivo efficacy were demonstrated to be the 5-fluoro group on the benzothiophene ring and the 4-imidazolyl moiety. Superimposition of 9k and 17 alpha-hydroxypregnenolone demonstrated their structural similarity and enabled rationalization of the pharmacological results. In addition, selected compounds were also identified to be potent inhibitors of human enzyme with IC(50) values of 20-30 nM.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New Advances in Chemical Research in 2021. Catalysts allow a reaction to proceed that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. name: 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene. Introducing a new discovery about 63675-74-1, Name is 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene

The present invention provides processes for preparing 2-substituted benzo[b]thiophene compounds, some of which are useful as intermediates for preparing pharmaceutically-active compounds and others which are useful, inter alia, for the treatment of osteoporosis in postmenopausal women.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: Product Details of 130-03-0, C8H6OS. A document type is Conference Paper, introducing its new discovery., Product Details of 130-03-0

3-Oxo-2,3-dihydrobenzo[b]furans, -thiophenes and -selenophenes 1a-c afforded the bromo-aldehydes 2 under Vilsmeier-Haack-Arnold conditions. Palladium-catalysed aryl-aryl coupling of 2 with o-formyl-phenylboronic acid allowed the formation of dialdehydes 3 which underwent McMurry cyclisation or pinacol condensation to yield polycyclic aromatic derivatives 4 or the dihydroxylated compounds 5.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthetic Route of 360575-29-7, Chemical Research Letters, May 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In a article, 360575-29-7, molcular formula is C10H7BrO2S, introducing its new discovery.

The present invention relates to the use of compounds that selectively bind to activated protein kinase G1 alpha for imaging the anatomic basis for chronic pain. Such imaging may also be used to objectively quantify chronic pain. Specifically, fluorine-18 and carbon -11 labeled NOP compouds, [18F] NOP46 and [11 C]NOP46, are disclosed for use as imaging agents for detecting and quantifying neuropathic pain.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New Advances in Chemical Research in 2021. Catalysts allow a reaction to proceed that has a lower activation energy than the uncatalyzed reaction. In heterogeneous catalysis, catalysts provide a surface to which reactants bind in a process of adsorption. Safety of Methyl 4-bromobenzo[b]thiophene-2-carboxylate. Introducing a new discovery about 360575-29-7, Name is Methyl 4-bromobenzo[b]thiophene-2-carboxylate

The present invention discloses a compound of the formula I as shown, or a stereoisomer thereof, or a pharmaceutically acceptable salt, or solvate thereof, or prodrug thereof, or its metabolic product. The test shows, the compounds of the invention has good ROCK inhibition activity, can be effectively used for ROCK activity with abnormal in the treatment of diseases, for the clinical treatment of diseases associated with abnormal active ROCK provides a new pharmaceutical may be. (by machine translation)

The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 360575-29-7

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. Safety of 3-(Bromomethyl)-5-chlorobenzo[b]thiophene. Introducing a new discovery about 1198-51-2, Name is 3-(Bromomethyl)-5-chlorobenzo[b]thiophene

The present invention provides an imidazopyridine compound represented by formula (I), wherein R1 and R2 each independently represent a C1-6 alkyl group et al; R3 and R4 each independently represent a hydrogen atom, a methyl et al; Ar1 is a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Ar2 represents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents -(CH2)m et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 5394-13-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 5394-13-8, Name is 2-Bromobenzo[b]thiophene,introducing its new discovery.

The present invention refers to the offending cycle including organic for electrical components including electrical component that organic compound and derivatives are disclosed. (by machine translation)

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chemical Research Letters, May 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction.category: benzothiophene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 63675-74-1, Name is 6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophene, molecular formula is C16H14O2S

The instant invention provides intermediates and processes for the preparation of compounds of formula IV STR1 wherein: n is 0, 1, or 2; R is hydrogen or C1 -C4 alkyl; X1 is hydrogen, cyano, 4-hydroxybenzoyl, 4-halobenzoyl, or 4-(C1 -C4 alkoxy)benzoyl; Y is NR4 R5, 4-hydroxyphenyl, or 4-(C1 -C4 alkoxy)phenyl; and R4 and R5 are independently hydrogen or C1 -C4 alkyl.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem