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The synthesis of benzothiophenes containing a piperazine side chain and their binding affinities for estrogen receptors are described. These compounds bearing piperazine side chains were identified to be high-affinity ligands with high selectivity for ER alpha subtype. They were also potent agonists in bone tissue.
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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem