The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction. Safety of 2-Bromobenzo[b]thiophene, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 5394-13-8, Name is 2-Bromobenzo[b]thiophene, molecular formula is C8H5BrS
The s-BuLi-sparteine base combination deprotonated the C-2? position of 1,2,3,4,5-pentamethylazaferrocene 1 and subsequent reaction with a range of electrophiles gave C-2 substituted products in 76-93% yield and ?80% ee. The products could be recrystallised to enrich ee’s to >90%. Resubjection of the initial addition products (?80% ee) to the deprotonation conditions led to a kinetic resolution to give products with >90% ee and superior overall yields compared to recrystallisation for the cases where the electrophiles were Ph2CO, MeI and Ph2S2. Transmetallation of the 2-lithiopentamethylazaferrocene (?80% ee) with ZnCl2 allowed palladium catalysed cross coupling with a variety of C-2 haloaryl, heteroaryl and vinyl groups to give some novel C-2? substituted pentamethylazaferrocene derivatives in 61-77% yield in 80% ee. Potential N,N-chelate ligands were recrystallised to >95% ee. A novel C 2-symmetric bis-pentamethylazaferrocene 10 could be synthesised by an iron catalysed oxidative coupling of the enatioenriched C-2 lithio derivative and in the presence of a PhMe-Et2O solvent mixture proceeded in 97% ee. This journal is The Royal Society of Chemistry.
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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem