Extracurricular laboratory:new discovery of 5-Bromobenzothiophene

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A novel series of benzo[b]thiophene diamine thrombin inhibitors with a conformationally restricted C3-side chain 3 was investigated. The constrained C3-side chain by a cyclohexyl ring contributed to not only an additive but also a synergistic effect on the thrombin inhibitory activity. The SAR studies resulted in the discovery of a potent thrombin inhibitor 27 that was over 750-fold more potent than the initial lead compound 1.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem