New Advances in Chemical Research in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 4923-87-9. Introducing a new discovery about 4923-87-9, Name is 5-Bromobenzothiophene
The functionalization of thiophenes is a fundamental and important reaction. Herein, we disclose iridium-catalyzed one-pot annulation reactions of (benzo)thiophenes with (hetero)aromatic or alpha,beta-unsaturated carboxylic acids, which afford thiophene-fused coumarin-type frameworks. Dearomatization reactions of 2-substituted thiophenes with alpha,beta-unsaturated carboxylic acids deliver various thiophene-containing spirocyclic products. The occurrence of two interconnected reactions provides direct evidence for a Heck-type pathway. The mechanistic scenario described herein is distinctly different from the SEAr and concerted metalation?protodemetalation (CMD) pathways encountered in the well-described oxidative C?H/C?H cross-coupling reactions of thiophenes with other heteroarenes.
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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem