Synthetic Route of 35212-85-2, Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative theoretical assessments of solvent structures. In a article, 35212-85-2, molcular formula is C10H9NO2S, introducing its new discovery.
A number of 3-phenylpiperazinylethyl pyrimido<5,4-b>benzofuran-2,4-dione and pyrimido<5,4-b>benzothiophene-2,4-dione derivatives 5-15 were designed as bioisosters of the previously reported pyrimido<5,4-b>indole-2,4-diones and synthesized starting from the 3-amino-2-carboxybenzofuran and benzothiophene ethyl and methyl esters respectively.They were evaluated for their in vitro alpha1-adrenoceptor and 5HT1A-receptor affinities by radioligand receptor binding assays.All target compounds showed good to excellent affinities for the alpha1-adrenoceptor with Ki values in the subnanomolar range.Some compounds were also good ligands for the 5HT1A-receptor with Ki values in the nanomolar range. 3-<2-<4-(2-Methoxyphenyl)piperazin-1-yl>ethyl>-1-methyl pyrimido<5,4-b>benzothiophen-2,4-dione 15 was the most active derivative in displacing <3H>-8-OH-DPAT from rat hippocampal membranes.There is evidence suggesting that the N1 methyl group of the tricyclic moiety of the title compounds is probably able to undergo a Van der Walls interaction at the 5HT1A-receptor binding site but not at the alpha1-adrenoceptor active site. pyrimido<5,4-b>benzofurans / pyrimido<5,4-b>benzothiophenes / alpha1-adrenoceptor binding / 5HT1A-receptor binding
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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem