Downstream synthetic route of 95-15-8

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.,95-15-8

To a solution of benzothiophene in dry THF (0.6 M) was added at -78C, BuLi (1.2 equiv) dropwise over 30 min. The mixture was stirred at -78C for 1 h, DMF (2 equiv) was added and the mixture was stirred for 1 h. Saturated NH4Cl was added and the mixture was extracted with EtOAc. The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated to give the title compound as an oil.

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference：
Patent; MERCK & CO., INC.; MERCK FROSST CANADA LTD.; WO2007/61764; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem