With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.
6314-28-9, To a dry 25mL round bottomed flask was added 44mg (0.25mmol) benzo[b]thiophene-2-carboxylic acid and excess (5mL) thionyl chloride, and the resulting mixture held at reflux for 3h. The resulting benzo[b]thiophene-2- carbonyl chloride was then evaporated to dryness via rotavap in preparation for the next step.
The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; PURDUE RESEARCH FOUNDATION; VAN RIJN, Richard M.; CUSHMAN, Mark S.; LILL, Markus; CASSELL, Robert James; ABDALLAH, Amr Hamed Mahmoud; ELSAYED, Mohamed S. A.; (28 pag.)WO2018/231635; (2018); A1;,
Benzothiophene – Wikipedia
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